Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

J. Nissen*, Betina Trabjerg, M. G. Pedersen, Karina Banasik, Ole Birger Pedersen, Erik Sørensen, Kaspar René Nielsen, Christian Erikstrup, Mikkel Steen Petersen, Helene Martina Paarup, P. Bruun-Rasmussen, D. Westergaard, T. F. Hansen, Carsten B. Pedersen, Thomas Werge, Fuller Torrey, Henrik Hjalgrim, Preben Bo Mortensen, Robert Yolken, Søren Brunak & 2 others Henrik Ullum, K. S. Burgdorf

*Corresponding author for this work

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Abstract

Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

Original languageEnglish
JournalPsychoneuroendocrinology
Volume108
Pages (from-to)150-154
ISSN0306-4530
DOIs
Publication statusPublished - 1. Oct 2019

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Human Herpesvirus 1
Population
International Classification of Diseases
Confidence Intervals
Case-Control Studies
Public Health
Odds Ratio
Incidence

Keywords

  • C-reactive protein
  • Herpes Simplex Virus type 1
  • Infection
  • Inflammation
  • Psychiatric disorders
  • Suicide

Cite this

Nissen, J. ; Trabjerg, Betina ; Pedersen, M. G. ; Banasik, Karina ; Pedersen, Ole Birger ; Sørensen, Erik ; Nielsen, Kaspar René ; Erikstrup, Christian ; Petersen, Mikkel Steen ; Paarup, Helene Martina ; Bruun-Rasmussen, P. ; Westergaard, D. ; Hansen, T. F. ; Pedersen, Carsten B. ; Werge, Thomas ; Torrey, Fuller ; Hjalgrim, Henrik ; Mortensen, Preben Bo ; Yolken, Robert ; Brunak, Søren ; Ullum, Henrik ; Burgdorf, K. S. / Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. In: Psychoneuroendocrinology. 2019 ; Vol. 108. pp. 150-154.
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title = "Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population",
abstract = "Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95{\%} confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95{\%} CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.",
keywords = "C-reactive protein, Herpes Simplex Virus type 1, Infection, Inflammation, Psychiatric disorders, Suicide",
author = "J. Nissen and Betina Trabjerg and Pedersen, {M. G.} and Karina Banasik and Pedersen, {Ole Birger} and Erik S{\o}rensen and Nielsen, {Kaspar Ren{\'e}} and Christian Erikstrup and Petersen, {Mikkel Steen} and Paarup, {Helene Martina} and P. Bruun-Rasmussen and D. Westergaard and Hansen, {T. F.} and Pedersen, {Carsten B.} and Thomas Werge and Fuller Torrey and Henrik Hjalgrim and Mortensen, {Preben Bo} and Robert Yolken and S{\o}ren Brunak and Henrik Ullum and Burgdorf, {K. S.}",
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doi = "10.1016/j.psyneuen.2019.06.015",
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Nissen, J, Trabjerg, B, Pedersen, MG, Banasik, K, Pedersen, OB, Sørensen, E, Nielsen, KR, Erikstrup, C, Petersen, MS, Paarup, HM, Bruun-Rasmussen, P, Westergaard, D, Hansen, TF, Pedersen, CB, Werge, T, Torrey, F, Hjalgrim, H, Mortensen, PB, Yolken, R, Brunak, S, Ullum, H & Burgdorf, KS 2019, 'Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population', Psychoneuroendocrinology, vol. 108, pp. 150-154. https://doi.org/10.1016/j.psyneuen.2019.06.015

Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. / Nissen, J.; Trabjerg, Betina; Pedersen, M. G.; Banasik, Karina; Pedersen, Ole Birger; Sørensen, Erik; Nielsen, Kaspar René; Erikstrup, Christian; Petersen, Mikkel Steen; Paarup, Helene Martina; Bruun-Rasmussen, P.; Westergaard, D.; Hansen, T. F.; Pedersen, Carsten B.; Werge, Thomas; Torrey, Fuller; Hjalgrim, Henrik; Mortensen, Preben Bo; Yolken, Robert; Brunak, Søren; Ullum, Henrik; Burgdorf, K. S.

In: Psychoneuroendocrinology, Vol. 108, 01.10.2019, p. 150-154.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

AU - Nissen, J.

AU - Trabjerg, Betina

AU - Pedersen, M. G.

AU - Banasik, Karina

AU - Pedersen, Ole Birger

AU - Sørensen, Erik

AU - Nielsen, Kaspar René

AU - Erikstrup, Christian

AU - Petersen, Mikkel Steen

AU - Paarup, Helene Martina

AU - Bruun-Rasmussen, P.

AU - Westergaard, D.

AU - Hansen, T. F.

AU - Pedersen, Carsten B.

AU - Werge, Thomas

AU - Torrey, Fuller

AU - Hjalgrim, Henrik

AU - Mortensen, Preben Bo

AU - Yolken, Robert

AU - Brunak, Søren

AU - Ullum, Henrik

AU - Burgdorf, K. S.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

AB - Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

KW - C-reactive protein

KW - Herpes Simplex Virus type 1

KW - Infection

KW - Inflammation

KW - Psychiatric disorders

KW - Suicide

U2 - 10.1016/j.psyneuen.2019.06.015

DO - 10.1016/j.psyneuen.2019.06.015

M3 - Journal article

VL - 108

SP - 150

EP - 154

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -