Heritability of retinal vascular fractals: a twin study

Anna Stage Vergmann, Rebecca Broe, Line Kessel, Jesper Leth Hougaard, Sören Möller, Kirsten Ohm Kyvik, Michael Larsen, Inger Christine Munch, Jakob Grauslund

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Abstract

Purpose:
To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.

Methods:
This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.

Results:
The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.

Conclusion:
In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the
Original languageEnglish
Publication date7. May 2017
Number of pages1
Publication statusPublished - 7. May 2017
EventAssociation for Research in Vision and Ophthalmology Annual Meeting 2017 - Baltimore, United States
Duration: 7. May 201711. May 2017

Conference

ConferenceAssociation for Research in Vision and Ophthalmology Annual Meeting 2017
CountryUnited States
CityBaltimore
Period07/05/201711/05/2017

Cite this

Vergmann, A. S., Broe, R., Kessel, L., Hougaard, J. L., Möller, S., Kyvik, K. O., ... Grauslund, J. (2017). Heritability of retinal vascular fractals: a twin study. Poster session presented at Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, United States.
Vergmann, Anna Stage ; Broe, Rebecca ; Kessel, Line ; Hougaard, Jesper Leth ; Möller, Sören ; Kyvik, Kirsten Ohm ; Larsen, Michael ; Munch, Inger Christine ; Grauslund, Jakob. / Heritability of retinal vascular fractals: a twin study. Poster session presented at Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, United States.1 p.
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title = "Heritability of retinal vascular fractals: a twin study",
abstract = "Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.Results: The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54{\%} of the variation was explained by dominant genetic effects and 46{\%} was individually environmentally determined.Conclusion: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54{\%} of the variation. The genetically predetermination of the",
author = "Vergmann, {Anna Stage} and Rebecca Broe and Line Kessel and Hougaard, {Jesper Leth} and S{\"o}ren M{\"o}ller and Kyvik, {Kirsten Ohm} and Michael Larsen and Munch, {Inger Christine} and Jakob Grauslund",
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Vergmann, AS, Broe, R, Kessel, L, Hougaard, JL, Möller, S, Kyvik, KO, Larsen, M, Munch, IC & Grauslund, J 2017, 'Heritability of retinal vascular fractals: a twin study', Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, United States, 07/05/2017 - 11/05/2017.

Heritability of retinal vascular fractals: a twin study. / Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line; Hougaard, Jesper Leth; Möller, Sören; Kyvik, Kirsten Ohm; Larsen, Michael; Munch, Inger Christine; Grauslund, Jakob.

2017. Poster session presented at Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, United States.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

TY - CONF

T1 - Heritability of retinal vascular fractals: a twin study

AU - Vergmann, Anna Stage

AU - Broe, Rebecca

AU - Kessel, Line

AU - Hougaard, Jesper Leth

AU - Möller, Sören

AU - Kyvik, Kirsten Ohm

AU - Larsen, Michael

AU - Munch, Inger Christine

AU - Grauslund, Jakob

PY - 2017/5/7

Y1 - 2017/5/7

N2 - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.Results: The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.Conclusion: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the

AB - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.Results: The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.Conclusion: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the

M3 - Poster

ER -

Vergmann AS, Broe R, Kessel L, Hougaard JL, Möller S, Kyvik KO et al. Heritability of retinal vascular fractals: a twin study. 2017. Poster session presented at Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, United States.