Heritability of hand eczema is not explained by comorbidity with atopic dermatitis

Anne Lerbaek, Kirsten O Kyvik, Jakob Mortensen, Lars E Bryld, Torkil Menné, Tove Agner

Research output: Contribution to journalJournal articleResearchpeer-review


Genetic factors have been shown to influence the risk of hand eczema, and may theoretically influence the frequency of eruptions as well as age at onset of the disease. However, the result may be confounded by atopic dermatitis, which is a major risk factor for development of hand eczema and is known to be influenced by genetic factors. In this study, the importance of genetic and environmental risk factors in the etiology of hand eczema, independent of atopic dermatitis, was investigated in a population-based twin cohort. In addition, any possible genetic influence on frequency of hand eczema eruptions and age at onset was explored. In all, 4,128 twin individuals
Original languageEnglish
JournalJournal of Investigative Dermatology
Issue number7
Pages (from-to)1632-1640
Number of pages9
Publication statusPublished - 1. Jul 2007


  • Adult
  • Cohort Studies
  • Comorbidity
  • Denmark
  • Dermatitis, Atopic
  • Diseases in Twins
  • Eczema
  • Environmental Exposure
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Hand
  • Health Surveys
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Risk Factors
  • Twins, Dizygotic
  • Twins, Monozygotic


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