Hepatitis B vaccination in prison with a 3-week schedule is more efficient than the standard 6-month schedule

Peer B Christensen, Niels Fisker, Henrik B Krarup, Elo Liebert, Nikolay Jaroslavtsev, Knud Christensen, J Georgsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A randomized study of injecting drug users in a Danish prison comparing vaccination at 0, 1 and 3 weeks with the 0, 1 and 6 months schedule (20microg Engerix B i.m.) was conducted. Due to a low participation rate, a second nonrandomized study was conducted in Estonia where all prisoners were vaccinated with the short schedule. In the randomized study, the compliance with three doses was 63% (12/19) in the 3-week schedule compared to 20% (3/15) in the 6-month schedule (P = 0.017). In the nonrandomized study, the compliance was 81% (457/566) and the seroprotection rate at month 7 was 67% (97/145), resulting in protection of 54% of the population at risk. This was significantly higher than the estimated 34-42% protection that would have been achieved with the 6-month schedule.

Original languageEnglish
JournalVaccine
Volume22
Issue number29-30
Pages (from-to)3897-3901
ISSN0264-410X
DOIs
Publication statusPublished - 2004

Keywords

  • Adult
  • Aged
  • Denmark
  • Estonia
  • Female
  • Hepatitis B
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Humans
  • Immunization Schedule
  • Male
  • Middle Aged
  • Prisoners
  • Substance Abuse, Intravenous
  • Vaccination
  • Vaccines, Synthetic

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