Hemodynamic and metabolic factors in the prediction of diastolic dysfunction

M. Nielsen, M. Pareek, T. B. Olesen, M. Leosdottir, P. M. Nilsson, M. H. Olsen

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

Objective: To explore possible hemodynamic and metabolic determinants of diastolic dysfunction in a random population sample. Design and method: We examined associations between hemodynamic factors (systolic blood pressure (SBP), heart rate (HR)), metabolic factors (fasting insulin, fasting plasma glucose, 2-hour glucose during oral glucose tolerance test (OGTT), oral disposition index (DIo), and Homeostatic Model Assessment (HOMA) derived indices of beta-cell function (HOMA-2B), insulin sensitivity (HOMA-2S), and insulin resistance (HOMA-2IR)), other traditional cardiovascular risk factors, and later detection of grade 2 or 3 diastolic dysfunction (DD) in 243 men and 22 women aged 28 to 57 years at the time of inclusion, using binary logistic regression analysis. Study subjects came from a random population based sample and were included 1974-1992, whilst the echocardiography was performed 2002-2006. Results: After a mean follow-up time of 27 years, grade 2 or 3 diastolic dysfunction was detected in 34% (n = 89) of subjects. In univariate analyses (significance level 0.05), diastolic dysfunction was associated with age, sex, heart rate, systolic blood pressure, fasting insulin levels, 2-hour glucose levels, HOMA-2B, HOMA- 2S, HOMA-2IR, and the time elapsed between inclusion and echocardiography. In multivariable analysis (significance level 0.20), sex (odds ratio (OR) = 6.08 (95% confidence interval (CI), 1.26-29.25); p = 0.02), heart rate (OR = 1.02 (95% CI, 0.996-1.05); p = 0.1), HOMA-2B (OR = 1.01 (95% CI, 1.00-1.01); p = 0.051), and time span (OR = 1.84 (95% CI, 1.73-1.96); p = 0.01), remained significantly associated with diastolic dysfunction, whereas age was forced into the model (OR = 1.03 (95% CI, 0.96-1.11); p = 0.41). We did not detect any significant interactions between HOMA-2B and other variables in the prediction of diastolic dysfunction. Conclusions: In a binary logistic regression model adjusted for age, sex, and time, HOMA-2B was significantly associated with the development of grade 2 or 3 diastolic dysfunction. It is suggested that subjects with increased HOMA-2B values may be at greater cardiovascular risk.
Original languageEnglish
Article numberPP.08.08
JournalJournal of Hypertension
Volume33
Issue numbere-Supplement 1
Pages (from-to)e202
Number of pages1
ISSN0263-6352
DOIs
Publication statusPublished - 2015
Event25th European Meeting on Hypertension and Cardiovascular Protection - Milano, Italy
Duration: 12. Jun 201515. Jun 2015

Conference

Conference25th European Meeting on Hypertension and Cardiovascular Protection
CountryItaly
CityMilano
Period12/06/201515/06/2015

Cite this

Nielsen, M. ; Pareek, M. ; Olesen, T. B. ; Leosdottir, M. ; Nilsson, P. M. ; Olsen, M. H. / Hemodynamic and metabolic factors in the prediction of diastolic dysfunction. In: Journal of Hypertension. 2015 ; Vol. 33, No. e-Supplement 1. pp. e202.
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title = "Hemodynamic and metabolic factors in the prediction of diastolic dysfunction",
abstract = "Objective: To explore possible hemodynamic and metabolic determinants of diastolic dysfunction in a random population sample. Design and method: We examined associations between hemodynamic factors (systolic blood pressure (SBP), heart rate (HR)), metabolic factors (fasting insulin, fasting plasma glucose, 2-hour glucose during oral glucose tolerance test (OGTT), oral disposition index (DIo), and Homeostatic Model Assessment (HOMA) derived indices of beta-cell function (HOMA-2B), insulin sensitivity (HOMA-2S), and insulin resistance (HOMA-2IR)), other traditional cardiovascular risk factors, and later detection of grade 2 or 3 diastolic dysfunction (DD) in 243 men and 22 women aged 28 to 57 years at the time of inclusion, using binary logistic regression analysis. Study subjects came from a random population based sample and were included 1974-1992, whilst the echocardiography was performed 2002-2006. Results: After a mean follow-up time of 27 years, grade 2 or 3 diastolic dysfunction was detected in 34{\%} (n = 89) of subjects. In univariate analyses (significance level 0.05), diastolic dysfunction was associated with age, sex, heart rate, systolic blood pressure, fasting insulin levels, 2-hour glucose levels, HOMA-2B, HOMA- 2S, HOMA-2IR, and the time elapsed between inclusion and echocardiography. In multivariable analysis (significance level 0.20), sex (odds ratio (OR) = 6.08 (95{\%} confidence interval (CI), 1.26-29.25); p = 0.02), heart rate (OR = 1.02 (95{\%} CI, 0.996-1.05); p = 0.1), HOMA-2B (OR = 1.01 (95{\%} CI, 1.00-1.01); p = 0.051), and time span (OR = 1.84 (95{\%} CI, 1.73-1.96); p = 0.01), remained significantly associated with diastolic dysfunction, whereas age was forced into the model (OR = 1.03 (95{\%} CI, 0.96-1.11); p = 0.41). We did not detect any significant interactions between HOMA-2B and other variables in the prediction of diastolic dysfunction. Conclusions: In a binary logistic regression model adjusted for age, sex, and time, HOMA-2B was significantly associated with the development of grade 2 or 3 diastolic dysfunction. It is suggested that subjects with increased HOMA-2B values may be at greater cardiovascular risk.",
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author = "M. Nielsen and M. Pareek and Olesen, {T. B.} and M. Leosdottir and Nilsson, {P. M.} and Olsen, {M. H.}",
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Hemodynamic and metabolic factors in the prediction of diastolic dysfunction. / Nielsen, M.; Pareek, M.; Olesen, T. B.; Leosdottir, M.; Nilsson, P. M.; Olsen, M. H.

In: Journal of Hypertension, Vol. 33, No. e-Supplement 1, PP.08.08, 2015, p. e202.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - Hemodynamic and metabolic factors in the prediction of diastolic dysfunction

AU - Nielsen, M.

AU - Pareek, M.

AU - Olesen, T. B.

AU - Leosdottir, M.

AU - Nilsson, P. M.

AU - Olsen, M. H.

PY - 2015

Y1 - 2015

N2 - Objective: To explore possible hemodynamic and metabolic determinants of diastolic dysfunction in a random population sample. Design and method: We examined associations between hemodynamic factors (systolic blood pressure (SBP), heart rate (HR)), metabolic factors (fasting insulin, fasting plasma glucose, 2-hour glucose during oral glucose tolerance test (OGTT), oral disposition index (DIo), and Homeostatic Model Assessment (HOMA) derived indices of beta-cell function (HOMA-2B), insulin sensitivity (HOMA-2S), and insulin resistance (HOMA-2IR)), other traditional cardiovascular risk factors, and later detection of grade 2 or 3 diastolic dysfunction (DD) in 243 men and 22 women aged 28 to 57 years at the time of inclusion, using binary logistic regression analysis. Study subjects came from a random population based sample and were included 1974-1992, whilst the echocardiography was performed 2002-2006. Results: After a mean follow-up time of 27 years, grade 2 or 3 diastolic dysfunction was detected in 34% (n = 89) of subjects. In univariate analyses (significance level 0.05), diastolic dysfunction was associated with age, sex, heart rate, systolic blood pressure, fasting insulin levels, 2-hour glucose levels, HOMA-2B, HOMA- 2S, HOMA-2IR, and the time elapsed between inclusion and echocardiography. In multivariable analysis (significance level 0.20), sex (odds ratio (OR) = 6.08 (95% confidence interval (CI), 1.26-29.25); p = 0.02), heart rate (OR = 1.02 (95% CI, 0.996-1.05); p = 0.1), HOMA-2B (OR = 1.01 (95% CI, 1.00-1.01); p = 0.051), and time span (OR = 1.84 (95% CI, 1.73-1.96); p = 0.01), remained significantly associated with diastolic dysfunction, whereas age was forced into the model (OR = 1.03 (95% CI, 0.96-1.11); p = 0.41). We did not detect any significant interactions between HOMA-2B and other variables in the prediction of diastolic dysfunction. Conclusions: In a binary logistic regression model adjusted for age, sex, and time, HOMA-2B was significantly associated with the development of grade 2 or 3 diastolic dysfunction. It is suggested that subjects with increased HOMA-2B values may be at greater cardiovascular risk.

AB - Objective: To explore possible hemodynamic and metabolic determinants of diastolic dysfunction in a random population sample. Design and method: We examined associations between hemodynamic factors (systolic blood pressure (SBP), heart rate (HR)), metabolic factors (fasting insulin, fasting plasma glucose, 2-hour glucose during oral glucose tolerance test (OGTT), oral disposition index (DIo), and Homeostatic Model Assessment (HOMA) derived indices of beta-cell function (HOMA-2B), insulin sensitivity (HOMA-2S), and insulin resistance (HOMA-2IR)), other traditional cardiovascular risk factors, and later detection of grade 2 or 3 diastolic dysfunction (DD) in 243 men and 22 women aged 28 to 57 years at the time of inclusion, using binary logistic regression analysis. Study subjects came from a random population based sample and were included 1974-1992, whilst the echocardiography was performed 2002-2006. Results: After a mean follow-up time of 27 years, grade 2 or 3 diastolic dysfunction was detected in 34% (n = 89) of subjects. In univariate analyses (significance level 0.05), diastolic dysfunction was associated with age, sex, heart rate, systolic blood pressure, fasting insulin levels, 2-hour glucose levels, HOMA-2B, HOMA- 2S, HOMA-2IR, and the time elapsed between inclusion and echocardiography. In multivariable analysis (significance level 0.20), sex (odds ratio (OR) = 6.08 (95% confidence interval (CI), 1.26-29.25); p = 0.02), heart rate (OR = 1.02 (95% CI, 0.996-1.05); p = 0.1), HOMA-2B (OR = 1.01 (95% CI, 1.00-1.01); p = 0.051), and time span (OR = 1.84 (95% CI, 1.73-1.96); p = 0.01), remained significantly associated with diastolic dysfunction, whereas age was forced into the model (OR = 1.03 (95% CI, 0.96-1.11); p = 0.41). We did not detect any significant interactions between HOMA-2B and other variables in the prediction of diastolic dysfunction. Conclusions: In a binary logistic regression model adjusted for age, sex, and time, HOMA-2B was significantly associated with the development of grade 2 or 3 diastolic dysfunction. It is suggested that subjects with increased HOMA-2B values may be at greater cardiovascular risk.

KW - diastolic dysfunction European hypertension protection prediction diet restriction heart rate model echocardiography oral glucose tolerance test logistic regression analysis human systolic blood pressure population cardiovascular risk insulin resistance i

U2 - 10.1097/01.hjh.0000467960.60608.5d

DO - 10.1097/01.hjh.0000467960.60608.5d

M3 - Conference abstract in journal

VL - 33

SP - e202

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - e-Supplement 1

M1 - PP.08.08

ER -