Heat penetration in locally applied hyperthermia in the abdomen during intra-operative hyperthermic intraperitoneal chemotherapy

S Van Ruth*, VJ Verwaal, AAM Hart, GW Van Slooten, FAN Zoetmulder

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C has been applied following cytoreductive surgery for various peritoneal surface malignancies. The aim of this study was to evaluate heat penetration in the abdomen during 10 HIPEC procedures. Materials and Methods: Temperature measurements were taken at 5 levels through the abdominal wall. Core temperature and room temperature were also measured. The relationships between the temperature gradient and room or core temperature were studied. Results: At the start Of perfusion, the temperature was estimated on average to be 40.6degreesC at the first level. then it decreased by 1.7degreesC (SD 1.0degreesC, p = 0.0001) in the first mm. In outward direction, it decreases by a further 1.5degreesC per cm (SD 0.3degreesC/cm, p

Original languageEnglish
JournalAnticancer Research
Volume23
Issue number2B
Pages (from-to)1501-1508
Number of pages8
ISSN0250-7005
Publication statusPublished - 2003
Externally publishedYes

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