Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study

J Burisch, P Weimers, N Pedersen, S Cukovic-Cavka, B Vucelic, I Kaimakliotis, D Duricova, M Bortlik, O Shonová, I Vind, S Avnstrøm, N Thorsgaard, S Krabbe, V Andersen, J F Dahlerup, J Kjeldsen, R Salupere, J Olsen, K R Nielsen, P ManninenP Collin, K H Katsanos, E V Tsianos, K Ladefoged, L Lakatos, G Ragnarsson, E Björnsson, Y Bailey, C O'Morain, D Schwartz, S Odes, D Valpiani, M C Boni, L Jonaitis, L Kupcinskas, S Turcan, L Barros, F Magro, D Lazar, A Goldis, I Nikulina, E Belousova, A Fernandez, L Sanroman, S Almer, Y Zhulina, J Halfvarson, N Arebi, T Diggory, S Sebastian, EpiCom Group

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.

METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.

RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.

CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

Original languageEnglish
JournalJournal of Crohn's and Colitis
Volume8
Issue number9
Pages (from-to)1030–1042
ISSN1873-9946
DOIs
Publication statusPublished - 20. Feb 2014

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Inflammatory Bowel Diseases
Quality of Life
Population
Ulcerative Colitis
Crohn Disease
Eastern Europe
Surveys and Questionnaires

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Burisch, J ; Weimers, P ; Pedersen, N ; Cukovic-Cavka, S ; Vucelic, B ; Kaimakliotis, I ; Duricova, D ; Bortlik, M ; Shonová, O ; Vind, I ; Avnstrøm, S ; Thorsgaard, N ; Krabbe, S ; Andersen, V ; Dahlerup, J F ; Kjeldsen, J ; Salupere, R ; Olsen, J ; Nielsen, K R ; Manninen, P ; Collin, P ; Katsanos, K H ; Tsianos, E V ; Ladefoged, K ; Lakatos, L ; Ragnarsson, G ; Björnsson, E ; Bailey, Y ; O'Morain, C ; Schwartz, D ; Odes, S ; Valpiani, D ; Boni, M C ; Jonaitis, L ; Kupcinskas, L ; Turcan, S ; Barros, L ; Magro, F ; Lazar, D ; Goldis, A ; Nikulina, I ; Belousova, E ; Fernandez, A ; Sanroman, L ; Almer, S ; Zhulina, Y ; Halfvarson, J ; Arebi, N ; Diggory, T ; Sebastian, S ; EpiCom Group. / Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease : An ECCO-EpiCom study. In: Journal of Crohn's and Colitis. 2014 ; Vol. 8, No. 9. pp. 1030–1042.
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title = "Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study",
abstract = "BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.",
author = "J Burisch and P Weimers and N Pedersen and S Cukovic-Cavka and B Vucelic and I Kaimakliotis and D Duricova and M Bortlik and O Shonov{\'a} and I Vind and S Avnstr{\o}m and N Thorsgaard and S Krabbe and V Andersen and Dahlerup, {J F} and J Kjeldsen and R Salupere and J Olsen and Nielsen, {K R} and P Manninen and P Collin and Katsanos, {K H} and Tsianos, {E V} and K Ladefoged and L Lakatos and G Ragnarsson and E Bj{\"o}rnsson and Y Bailey and C O'Morain and D Schwartz and S Odes and D Valpiani and Boni, {M C} and L Jonaitis and L Kupcinskas and S Turcan and L Barros and F Magro and D Lazar and A Goldis and I Nikulina and E Belousova and A Fernandez and L Sanroman and S Almer and Y Zhulina and J Halfvarson and N Arebi and T Diggory and S Sebastian and {EpiCom Group}",
note = "Copyright {\circledC} 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.",
year = "2014",
month = "2",
day = "20",
doi = "10.1016/j.crohns.2014.01.028",
language = "English",
volume = "8",
pages = "1030–1042",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Heinemann",
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Burisch, J, Weimers, P, Pedersen, N, Cukovic-Cavka, S, Vucelic, B, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, JF, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, KR, Manninen, P, Collin, P, Katsanos, KH, Tsianos, EV, Ladefoged, K, Lakatos, L, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Valpiani, D, Boni, MC, Jonaitis, L, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Fernandez, A, Sanroman, L, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Diggory, T, Sebastian, S & EpiCom Group 2014, 'Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study', Journal of Crohn's and Colitis, vol. 8, no. 9, pp. 1030–1042. https://doi.org/10.1016/j.crohns.2014.01.028

Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease : An ECCO-EpiCom study. / Burisch, J; Weimers, P; Pedersen, N; Cukovic-Cavka, S; Vucelic, B; Kaimakliotis, I; Duricova, D; Bortlik, M; Shonová, O; Vind, I; Avnstrøm, S; Thorsgaard, N; Krabbe, S; Andersen, V; Dahlerup, J F; Kjeldsen, J; Salupere, R; Olsen, J; Nielsen, K R; Manninen, P; Collin, P; Katsanos, K H; Tsianos, E V; Ladefoged, K; Lakatos, L; Ragnarsson, G; Björnsson, E; Bailey, Y; O'Morain, C; Schwartz, D; Odes, S; Valpiani, D; Boni, M C; Jonaitis, L; Kupcinskas, L; Turcan, S; Barros, L; Magro, F; Lazar, D; Goldis, A; Nikulina, I; Belousova, E; Fernandez, A; Sanroman, L; Almer, S; Zhulina, Y; Halfvarson, J; Arebi, N; Diggory, T; Sebastian, S; EpiCom Group.

In: Journal of Crohn's and Colitis, Vol. 8, No. 9, 20.02.2014, p. 1030–1042.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease

T2 - An ECCO-EpiCom study

AU - Burisch, J

AU - Weimers, P

AU - Pedersen, N

AU - Cukovic-Cavka, S

AU - Vucelic, B

AU - Kaimakliotis, I

AU - Duricova, D

AU - Bortlik, M

AU - Shonová, O

AU - Vind, I

AU - Avnstrøm, S

AU - Thorsgaard, N

AU - Krabbe, S

AU - Andersen, V

AU - Dahlerup, J F

AU - Kjeldsen, J

AU - Salupere, R

AU - Olsen, J

AU - Nielsen, K R

AU - Manninen, P

AU - Collin, P

AU - Katsanos, K H

AU - Tsianos, E V

AU - Ladefoged, K

AU - Lakatos, L

AU - Ragnarsson, G

AU - Björnsson, E

AU - Bailey, Y

AU - O'Morain, C

AU - Schwartz, D

AU - Odes, S

AU - Valpiani, D

AU - Boni, M C

AU - Jonaitis, L

AU - Kupcinskas, L

AU - Turcan, S

AU - Barros, L

AU - Magro, F

AU - Lazar, D

AU - Goldis, A

AU - Nikulina, I

AU - Belousova, E

AU - Fernandez, A

AU - Sanroman, L

AU - Almer, S

AU - Zhulina, Y

AU - Halfvarson, J

AU - Arebi, N

AU - Diggory, T

AU - Sebastian, S

AU - EpiCom Group

N1 - Copyright © 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

PY - 2014/2/20

Y1 - 2014/2/20

N2 - BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

AB - BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

U2 - 10.1016/j.crohns.2014.01.028

DO - 10.1016/j.crohns.2014.01.028

M3 - Journal article

C2 - 24560877

VL - 8

SP - 1030

EP - 1042

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 9

ER -