Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning

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Abstract

Physical functioning late in life has been shown to be affected by genetic factors. Only a few genetic variants have been suggested to be associated with physical functioning, and this only in selected populations (e.g., young healthy males and elite athletes). Declining physical functioning late in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known to be associated with muscular functioning in other muscle groups and with activities of daily living (ADL) functioning, and it predicts incident disability. We studied 1,757 Danish twin pairs aged 45-96 years, and found that this phenotype has a heritability of 52% (95% confidence interval (CI), 48-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid- and late-life physical functioning.
Original languageEnglish
JournalGenetic Epidemiology
Volume23
Issue number2
Pages (from-to)110-122
Number of pages12
ISSN0741-0395
DOIs
Publication statusPublished - 2002

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Dizygotic Twins
Athletes
Quality of Life
Confidence Intervals
Muscles
Population

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@article{565c6290ba9911dc9626000ea68e967b,
title = "Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning",
abstract = "Physical functioning late in life has been shown to be affected by genetic factors. Only a few genetic variants have been suggested to be associated with physical functioning, and this only in selected populations (e.g., young healthy males and elite athletes). Declining physical functioning late in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known to be associated with muscular functioning in other muscle groups and with activities of daily living (ADL) functioning, and it predicts incident disability. We studied 1,757 Danish twin pairs aged 45-96 years, and found that this phenotype has a heritability of 52{\%} (95{\%} confidence interval (CI), 48-55{\%}). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid- and late-life physical functioning.",
author = "Henrik Frederiksen and David Gaist and Petersen, {Hans Christian} and Jacob Hjelmborg and Matt McGue and Vaupel, {James W} and Kaare Christensen",
year = "2002",
doi = "10.1002/gepi.1127",
language = "English",
volume = "23",
pages = "110--122",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

TY - JOUR

T1 - Hand grip strength

T2 - A phenotype suitable for identifying genetic variants affecting mid- and late-life physical functioning

AU - Frederiksen, Henrik

AU - Gaist, David

AU - Petersen, Hans Christian

AU - Hjelmborg, Jacob

AU - McGue, Matt

AU - Vaupel, James W

AU - Christensen, Kaare

PY - 2002

Y1 - 2002

N2 - Physical functioning late in life has been shown to be affected by genetic factors. Only a few genetic variants have been suggested to be associated with physical functioning, and this only in selected populations (e.g., young healthy males and elite athletes). Declining physical functioning late in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known to be associated with muscular functioning in other muscle groups and with activities of daily living (ADL) functioning, and it predicts incident disability. We studied 1,757 Danish twin pairs aged 45-96 years, and found that this phenotype has a heritability of 52% (95% confidence interval (CI), 48-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid- and late-life physical functioning.

AB - Physical functioning late in life has been shown to be affected by genetic factors. Only a few genetic variants have been suggested to be associated with physical functioning, and this only in selected populations (e.g., young healthy males and elite athletes). Declining physical functioning late in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known to be associated with muscular functioning in other muscle groups and with activities of daily living (ADL) functioning, and it predicts incident disability. We studied 1,757 Danish twin pairs aged 45-96 years, and found that this phenotype has a heritability of 52% (95% confidence interval (CI), 48-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid- and late-life physical functioning.

U2 - 10.1002/gepi.1127

DO - 10.1002/gepi.1127

M3 - Journal article

C2 - 12214305

VL - 23

SP - 110

EP - 122

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - 2

ER -