Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study

Theresa Gmelin, Andrea Rosso, Stacy Andersen, Stephanie Cosentino, Mary Wojczynski, Kaare Christensen, Robert Boudreau, Nancy Glynn

Research output: Contribution to journalConference abstract in journalResearchpeer-review

8 Downloads (Pure)


Greater perceived physical fatigability is associated with physical functional decline, but few studies have examined its relation with cognition. Adults ≥60 (mean±SD age 73.7±10.5, 54.7\ 99.6\ from the Long Life Family Study (n=2355) completed the Pittsburgh Fatigability Scale (PFS, 0-50, higher=greater fatigability) and a neurocognitive examination. Generalized estimating equations were used to account for family structure. Covariates included age, sex, field center, depressive symptoms (Center for Epidemiological Studies-Depression), education, and self-reported health. Each 1-point greater PFS was associated with lower: (1) global cognition (Mini-Mental Status Exam; β=-0.36,p\lt;.0001), (2) verbal fluency (phonemic: β=-0.09,p=.029 and semantic: β=-0.14,p\lt;.0001), (3) memory (Hopkins Verbal Learning Test-Revised: β=-0.06,p=.037), and (4) psychomotor speed (Digit Symbol Substitution Test: β=-0.10,p\lt;.0001), after covariate adjustment. Greater perceived physical fatigability was significantly associated with lower memory and cognitive function in older adults, and may represent a promising new biomarker of biological aging reflecting declining brain reserve, resilience, and neurodegeneration.
Original languageEnglish
JournalInnovation in Aging
Issue numberSuppl. 1
Pages (from-to)782-783
Number of pages2
Publication statusPublished - 2020
EventGSA 2020 Annual Scientific Meeting Online -
Duration: 4. Nov 20207. Nov 2020


ConferenceGSA 2020 Annual Scientific Meeting Online
Internet address

Cite this