GPC-modalities for Neurophotonics and Optogenetics

Jesper Glückstad*, René L. Eriksen, Andreas Gejl Madsen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

The powerful discipline of optogenetics can be described as “the branch of biotechnology which combines genetic engineering with optics to observe and control the function of genetically targeted groups of cells with light”. Using advanced laser beam-shaping such as Generalized Phase Contrast (GPC) and derived holographic modalities makes it possible to take advantage of cutting-edge two-photon technology to develop an unprecedented ‘circuit optogenetics’ platform with both high spatio-temporal selectivity and high penetration depth without disturbing speckle-noise. We will report on the latest laser shaping GPC-modalities with temporal focusing to uniquely sculpt patterns of one- and two-photon excitations for living neural-circuits and genetically modified light-sensitive cells.
Original languageEnglish
Title of host publicationComplex Light and Optical Forces XV
EditorsEnrique J. Galvez, Halina Rubinsztein-Dunlop, David L. Andrews
Number of pages7
Volume11701
PublisherSPIE - International Society for Optical Engineering
Publication date2021
ISBN (Electronic)9781510642379
DOIs
Publication statusPublished - 2021
EventSpie Opto - Online, California, United States
Duration: 6. Mar 202112. Mar 2021

Conference

ConferenceSpie Opto
Country/TerritoryUnited States
CityOnline, California
Period06/03/202112/03/2021

Keywords

  • Generalized Phase Contrast (GPC)
  • Neurophotonics
  • Optogenetics

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