Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study

Pasi J. Eskola, Per Kjær, Iita M. Daavittila, Svetlana Solovieva, Annaleena Okuloff, Joan S. Sorensen, Niels Wedderkopp, Leena Ala-Kokko, Minna Männikkö, Jaro I Karppinen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The objective of the present study was to examine the associations between eleven putative predisposing
single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The
population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance im-
ages (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logis-
tic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36
girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6
promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71-
26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associaamong boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.


Original languageEnglish
JournalInternational Journal of Molecular Epidemiology and Genetics
Volume1
Issue number2
Pages (from-to)158-165
Number of pages8
Publication statusPublished - 29. Mar 2010

Keywords

  • Disc degeneration, children, genetics, interleukins

Fingerprint Dive into the research topics of 'Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study'. Together they form a unique fingerprint.

Cite this