Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study

Pasi J. Eskola; Per Kjær; Iita M. Daavittila; Svetlana Solovieva; Annaleena Okuloff; Joan S. Sorensen; Niels Wedderkopp; Leena Ala-Kokko; Minna Männikkö; Jaro I Karppinen

Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study

Pasi J. Eskola, Per Kjær, Iita M. Daavittila, Svetlana Solovieva, Annaleena Okuloff, Joan S. Sorensen, Niels Wedderkopp, Leena Ala-Kokko, Minna Männikkö, Jaro I Karppinen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The objective of the present study was to examine the associations between eleven putative predisposing
single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The
population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance im-
ages (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logis-
tic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36
girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6
promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71-
26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associaamong boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.

Original language	English
Journal	International Journal of Molecular Epidemiology and Genetics
Volume	1
Issue number	2
Pages (from-to)	158-165
Number of pages	8
Publication status	Published - 29. Mar 2010

Keywords

Disc degeneration, children, genetics, interleukins

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http://www.ijmeg.org/files/IJMEG912002.pdf

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Eskola, P. J., Kjær, P., Daavittila, I. M., Solovieva, S., Okuloff, A., Sorensen, J. S., Wedderkopp, N., Ala-Kokko, L., Männikkö, M., & Karppinen, J. I. (2010). Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study. International Journal of Molecular Epidemiology and Genetics, 1(2), 158-165. http://www.ijmeg.org/files/IJMEG912002.pdf

Eskola, Pasi J. ; Kjær, Per ; Daavittila, Iita M. ; Solovieva, Svetlana ; Okuloff, Annaleena ; Sorensen, Joan S. ; Wedderkopp, Niels ; Ala-Kokko, Leena ; Männikkö, Minna ; Karppinen, Jaro I. / Genetic risk factors of disc degeneration among 12-14-year-old Danish children : a population study. In: International Journal of Molecular Epidemiology and Genetics. 2010 ; Vol. 1, No. 2. pp. 158-165.

@article{9c1daa0068c511df9ac3000ea68e967b,

title = "Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study",

abstract = "The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance im- ages (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logis- tic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36 girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6 promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71- 26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associaamong boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls. ",

keywords = "Disc degeneration, children, genetics, interleukins",

author = "Eskola, {Pasi J.} and Per Kj{\ae}r and Daavittila, {Iita M.} and Svetlana Solovieva and Annaleena Okuloff and Sorensen, {Joan S.} and Niels Wedderkopp and Leena Ala-Kokko and Minna M{\"a}nnikk{\"o} and Karppinen, {Jaro I}",

year = "2010",

month = mar,

day = "29",

language = "English",

volume = "1",

pages = "158--165",

journal = "International Journal of Molecular Epidemiology and Genetics",

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Eskola, PJ, Kjær, P, Daavittila, IM, Solovieva, S, Okuloff, A, Sorensen, JS, Wedderkopp, N, Ala-Kokko, L, Männikkö, M & Karppinen, JI 2010, 'Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study', International Journal of Molecular Epidemiology and Genetics, vol. 1, no. 2, pp. 158-165. <http://www.ijmeg.org/files/IJMEG912002.pdf>

Genetic risk factors of disc degeneration among 12-14-year-old Danish children : a population study. / Eskola, Pasi J.; Kjær, Per; Daavittila, Iita M.; Solovieva, Svetlana; Okuloff, Annaleena; Sorensen, Joan S.; Wedderkopp, Niels; Ala-Kokko, Leena; Männikkö, Minna; Karppinen, Jaro I.

In: International Journal of Molecular Epidemiology and Genetics, Vol. 1, No. 2, 29.03.2010, p. 158-165.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Genetic risk factors of disc degeneration among 12-14-year-old Danish children

T2 - a population study

AU - Eskola, Pasi J.

AU - Kjær, Per

AU - Daavittila, Iita M.

AU - Solovieva, Svetlana

AU - Okuloff, Annaleena

AU - Sorensen, Joan S.

AU - Wedderkopp, Niels

AU - Ala-Kokko, Leena

AU - Männikkö, Minna

AU - Karppinen, Jaro I

PY - 2010/3/29

Y1 - 2010/3/29

N2 - The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance im- ages (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logis- tic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36 girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6 promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71- 26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associaamong boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.

AB - The objective of the present study was to examine the associations between eleven putative predisposing single nucleotide polymorphisms (COL9A3, COL11A2, IL1A, IL1B, IL6 and VDR) and early disc degeneration (DD). The population consisted of 12 to 14-year-old Danish children (N=352). DD was evaluated from magnetic resonance im- ages (MRI). We analysed the association between DD and single nucleotide polymorphisms or haplotypes using logis- tic regression analyses. Of the 352 children studied, 73 boys and 81 girls had no MRI changes, while 30 boys and 36 girls had lumbar DD. Among girls, IL1A rs1800587 in CT/TT compared to CC resulted in OR 2.85 [1.19-6.83]. In IL6 promoter polymorphism rs1800796, the C-allele was more frequent among the subjects with DD, OR 6.71 [1.71- 26.3]. Of the IL6 haplotypes, GCG was associated with DD, OR 6.46 [1.61 – 26.0]. No associaamong boys. Our results suggest possible roles for IL1A and IL6 in early DD among girls.

KW - Disc degeneration, children, genetics, interleukins

M3 - Journal article

VL - 1

SP - 158

EP - 165

JO - International Journal of Molecular Epidemiology and Genetics

JF - International Journal of Molecular Epidemiology and Genetics

SN - 1948-1756

IS - 2

ER -