Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

Ann Sophie Lønnberg, Lone Skov, David Lorenzo Duffy, Axel Skytthe, Kirsten Ohm Kyvik, Ole Birger Pedersen, Simon Francis Thomsen

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Abstract

The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

Original languageEnglish
Journal Acta Dermato-Venereologica
Volume96
Issue number1
Pages (from-to)35-38
ISSN0001-5555
DOIs
Publication statusPublished - Jan 2016

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Twin Studies
Age of Onset
Psoriasis
Population
Dizygotic Twins
Monozygotic Twins
Survival Analysis
Registries
Regression Analysis

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Lønnberg, Ann Sophie ; Skov, Lone ; Duffy, David Lorenzo ; Skytthe, Axel ; Kyvik, Kirsten Ohm ; Pedersen, Ole Birger ; Thomsen, Simon Francis. / Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. In: Acta Dermato-Venereologica. 2016 ; Vol. 96, No. 1. pp. 35-38.
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abstract = "The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.",
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Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. / Lønnberg, Ann Sophie; Skov, Lone; Duffy, David Lorenzo; Skytthe, Axel; Kyvik, Kirsten Ohm; Pedersen, Ole Birger; Thomsen, Simon Francis.

In: Acta Dermato-Venereologica, Vol. 96, No. 1, 01.2016, p. 35-38.

Research output: Contribution to journalJournal articleResearchpeer-review

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AU - Lønnberg, Ann Sophie

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AU - Duffy, David Lorenzo

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Pedersen, Ole Birger

AU - Thomsen, Simon Francis

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AB - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

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