Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Aline Jelenkovic, Reijo Sund, Yoon-Mi Hur, Yoshie Yokoyama, Jacob V B Hjelmborg, Sören Möller, Chika Honda, Patrik K E Magnusson, Nancy L Pedersen, Syuichi Ooki, Sari Aaltonen, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Duarte L Freitas, José Antonio Maia, Fuling Ji, Feng Ning, Zengchang Pang, Esther RebatoAndreas Busjahn, Christian Kandler, Kimberly J Saudino, Kerry L Jang, Wendy Cozen, Amie E Hwang, Thomas M Mack, Wenjing Gao, Canqing Yu, Liming Li, Robin P Corley, Brooke M Huibregtse, Catherine A Derom, Robert F Vlietinck, Ruth J F Loos, Kauko Heikkilä, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Tom A McAdams, Thalia C Eley, Alice M Gregory, Mingguang He, Xiaohu Ding, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David L Tarnoki, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S Alexandra Burt, Kelly L Klump, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Robert F Krueger, Matt McGue, Shandell Pahlen, Margaret Gatz, David A Butler, Meike Bartels, Toos C E M van Beijsterveldt, Jeffrey M Craig, Richard Saffery, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Gary E Swan, Ruth Krasnow, Per Tynelius, Paul Lichtenstein, Claire M A Haworth, Robert Plomin, Gombojav Bayasgalan, Danshiitsoodol Narandalai, K Paige Harden, Elliot M Tucker-Drob, Timothy Spector, Massimo Mangino, Genevieve Lachance, Laura A Baker, Catherine Tuvblad, Glen E Duncan, Dedra Buchwald, Gonneke Willemsen, Axel Skytthe, Kirsten O Kyvik, Kaare Christensen, Sevgi Y Öncel, Fazil Aliev, Finn Rasmussen, Jack H Goldberg, Thorkild I A Sørensen, Dorret I Boomsma, Jaakko Kaprio, Karri Silventoinen

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Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Original languageEnglish
Article number28496
JournalScientific Reports
Volume6
ISSN2045-2322
DOIs
Publication statusPublished - 2016

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Jelenkovic, Aline ; Sund, Reijo ; Hur, Yoon-Mi ; Yokoyama, Yoshie ; Hjelmborg, Jacob V B ; Möller, Sören ; Honda, Chika ; Magnusson, Patrik K E ; Pedersen, Nancy L ; Ooki, Syuichi ; Aaltonen, Sari ; Stazi, Maria A ; Fagnani, Corrado ; D'Ippolito, Cristina ; Freitas, Duarte L ; Maia, José Antonio ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Rebato, Esther ; Busjahn, Andreas ; Kandler, Christian ; Saudino, Kimberly J ; Jang, Kerry L ; Cozen, Wendy ; Hwang, Amie E ; Mack, Thomas M ; Gao, Wenjing ; Yu, Canqing ; Li, Liming ; Corley, Robin P ; Huibregtse, Brooke M ; Derom, Catherine A ; Vlietinck, Robert F ; Loos, Ruth J F ; Heikkilä, Kauko ; Wardle, Jane ; Llewellyn, Clare H ; Fisher, Abigail ; McAdams, Tom A ; Eley, Thalia C ; Gregory, Alice M ; He, Mingguang ; Ding, Xiaohu ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Tarnoki, Adam D ; Tarnoki, David L ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Burt, S Alexandra ; Klump, Kelly L ; Silberg, Judy L ; Eaves, Lindon J ; Maes, Hermine H ; Krueger, Robert F ; McGue, Matt ; Pahlen, Shandell ; Gatz, Margaret ; Butler, David A ; Bartels, Meike ; van Beijsterveldt, Toos C E M ; Craig, Jeffrey M ; Saffery, Richard ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Martin, Nicholas G ; Medland, Sarah E ; Montgomery, Grant W ; Swan, Gary E ; Krasnow, Ruth ; Tynelius, Per ; Lichtenstein, Paul ; Haworth, Claire M A ; Plomin, Robert ; Bayasgalan, Gombojav ; Narandalai, Danshiitsoodol ; Harden, K Paige ; Tucker-Drob, Elliot M ; Spector, Timothy ; Mangino, Massimo ; Lachance, Genevieve ; Baker, Laura A ; Tuvblad, Catherine ; Duncan, Glen E ; Buchwald, Dedra ; Willemsen, Gonneke ; Skytthe, Axel ; Kyvik, Kirsten O ; Christensen, Kaare ; Öncel, Sevgi Y ; Aliev, Fazil ; Rasmussen, Finn ; Goldberg, Jack H ; Sørensen, Thorkild I A ; Boomsma, Dorret I ; Kaprio, Jaakko ; Silventoinen, Karri. / Genetic and environmental influences on height from infancy to early adulthood : An individual-based pooled analysis of 45 twin cohorts. In: Scientific Reports. 2016 ; Vol. 6.
@article{ca117705123b4e20bdf78976db5ec9fb,
title = "Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts",
abstract = "Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.",
author = "Aline Jelenkovic and Reijo Sund and Yoon-Mi Hur and Yoshie Yokoyama and Hjelmborg, {Jacob V B} and S{\"o}ren M{\"o}ller and Chika Honda and Magnusson, {Patrik K E} and Pedersen, {Nancy L} and Syuichi Ooki and Sari Aaltonen and Stazi, {Maria A} and Corrado Fagnani and Cristina D'Ippolito and Freitas, {Duarte L} and Maia, {Jos{\'e} Antonio} and Fuling Ji and Feng Ning and Zengchang Pang and Esther Rebato and Andreas Busjahn and Christian Kandler and Saudino, {Kimberly J} and Jang, {Kerry L} and Wendy Cozen and Hwang, {Amie E} and Mack, {Thomas M} and Wenjing Gao and Canqing Yu and Liming Li and Corley, {Robin P} and Huibregtse, {Brooke M} and Derom, {Catherine A} and Vlietinck, {Robert F} and Loos, {Ruth J F} and Kauko Heikkil{\"a} and Jane Wardle and Llewellyn, {Clare H} and Abigail Fisher and McAdams, {Tom A} and Eley, {Thalia C} and Gregory, {Alice M} and Mingguang He and Xiaohu Ding and Morten Bjerregaard-Andersen and Henning Beck-Nielsen and Morten Sodemann and Tarnoki, {Adam D} and Tarnoki, {David L} and Ariel Knafo-Noam and David Mankuta and Lior Abramson and Burt, {S Alexandra} and Klump, {Kelly L} and Silberg, {Judy L} and Eaves, {Lindon J} and Maes, {Hermine H} and Krueger, {Robert F} and Matt McGue and Shandell Pahlen and Margaret Gatz and Butler, {David A} and Meike Bartels and {van Beijsterveldt}, {Toos C E M} and Craig, {Jeffrey M} and Richard Saffery and Lise Dubois and Michel Boivin and Mara Brendgen and Ginette Dionne and Frank Vitaro and Martin, {Nicholas G} and Medland, {Sarah E} and Montgomery, {Grant W} and Swan, {Gary E} and Ruth Krasnow and Per Tynelius and Paul Lichtenstein and Haworth, {Claire M A} and Robert Plomin and Gombojav Bayasgalan and Danshiitsoodol Narandalai and Harden, {K Paige} and Tucker-Drob, {Elliot M} and Timothy Spector and Massimo Mangino and Genevieve Lachance and Baker, {Laura A} and Catherine Tuvblad and Duncan, {Glen E} and Dedra Buchwald and Gonneke Willemsen and Axel Skytthe and Kyvik, {Kirsten O} and Kaare Christensen and {\"O}ncel, {Sevgi Y} and Fazil Aliev and Finn Rasmussen and Goldberg, {Jack H} and S{\o}rensen, {Thorkild I A} and Boomsma, {Dorret I} and Jaakko Kaprio and Karri Silventoinen",
year = "2016",
doi = "10.1038/srep28496",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

Jelenkovic, A, Sund, R, Hur, Y-M, Yokoyama, Y, Hjelmborg, JVB, Möller, S, Honda, C, Magnusson, PKE, Pedersen, NL, Ooki, S, Aaltonen, S, Stazi, MA, Fagnani, C, D'Ippolito, C, Freitas, DL, Maia, JA, Ji, F, Ning, F, Pang, Z, Rebato, E, Busjahn, A, Kandler, C, Saudino, KJ, Jang, KL, Cozen, W, Hwang, AE, Mack, TM, Gao, W, Yu, C, Li, L, Corley, RP, Huibregtse, BM, Derom, CA, Vlietinck, RF, Loos, RJF, Heikkilä, K, Wardle, J, Llewellyn, CH, Fisher, A, McAdams, TA, Eley, TC, Gregory, AM, He, M, Ding, X, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Knafo-Noam, A, Mankuta, D, Abramson, L, Burt, SA, Klump, KL, Silberg, JL, Eaves, LJ, Maes, HH, Krueger, RF, McGue, M, Pahlen, S, Gatz, M, Butler, DA, Bartels, M, van Beijsterveldt, TCEM, Craig, JM, Saffery, R, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Martin, NG, Medland, SE, Montgomery, GW, Swan, GE, Krasnow, R, Tynelius, P, Lichtenstein, P, Haworth, CMA, Plomin, R, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Spector, T, Mangino, M, Lachance, G, Baker, LA, Tuvblad, C, Duncan, GE, Buchwald, D, Willemsen, G, Skytthe, A, Kyvik, KO, Christensen, K, Öncel, SY, Aliev, F, Rasmussen, F, Goldberg, JH, Sørensen, TIA, Boomsma, DI, Kaprio, J & Silventoinen, K 2016, 'Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts', Scientific Reports, vol. 6, 28496. https://doi.org/10.1038/srep28496

Genetic and environmental influences on height from infancy to early adulthood : An individual-based pooled analysis of 45 twin cohorts. / Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi; Yokoyama, Yoshie; Hjelmborg, Jacob V B; Möller, Sören; Honda, Chika; Magnusson, Patrik K E; Pedersen, Nancy L; Ooki, Syuichi; Aaltonen, Sari; Stazi, Maria A; Fagnani, Corrado; D'Ippolito, Cristina; Freitas, Duarte L; Maia, José Antonio; Ji, Fuling; Ning, Feng; Pang, Zengchang; Rebato, Esther; Busjahn, Andreas; Kandler, Christian; Saudino, Kimberly J; Jang, Kerry L; Cozen, Wendy; Hwang, Amie E; Mack, Thomas M; Gao, Wenjing; Yu, Canqing; Li, Liming; Corley, Robin P; Huibregtse, Brooke M; Derom, Catherine A; Vlietinck, Robert F; Loos, Ruth J F; Heikkilä, Kauko; Wardle, Jane; Llewellyn, Clare H; Fisher, Abigail; McAdams, Tom A; Eley, Thalia C; Gregory, Alice M; He, Mingguang; Ding, Xiaohu; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D; Tarnoki, David L; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Burt, S Alexandra; Klump, Kelly L; Silberg, Judy L; Eaves, Lindon J; Maes, Hermine H; Krueger, Robert F; McGue, Matt; Pahlen, Shandell; Gatz, Margaret; Butler, David A; Bartels, Meike; van Beijsterveldt, Toos C E M; Craig, Jeffrey M; Saffery, Richard; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Martin, Nicholas G; Medland, Sarah E; Montgomery, Grant W; Swan, Gary E; Krasnow, Ruth; Tynelius, Per; Lichtenstein, Paul; Haworth, Claire M A; Plomin, Robert; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Harden, K Paige; Tucker-Drob, Elliot M; Spector, Timothy; Mangino, Massimo; Lachance, Genevieve; Baker, Laura A; Tuvblad, Catherine; Duncan, Glen E; Buchwald, Dedra; Willemsen, Gonneke; Skytthe, Axel; Kyvik, Kirsten O; Christensen, Kaare; Öncel, Sevgi Y; Aliev, Fazil; Rasmussen, Finn; Goldberg, Jack H; Sørensen, Thorkild I A; Boomsma, Dorret I; Kaprio, Jaakko; Silventoinen, Karri.

In: Scientific Reports, Vol. 6, 28496, 2016.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Genetic and environmental influences on height from infancy to early adulthood

T2 - An individual-based pooled analysis of 45 twin cohorts

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Hur, Yoon-Mi

AU - Yokoyama, Yoshie

AU - Hjelmborg, Jacob V B

AU - Möller, Sören

AU - Honda, Chika

AU - Magnusson, Patrik K E

AU - Pedersen, Nancy L

AU - Ooki, Syuichi

AU - Aaltonen, Sari

AU - Stazi, Maria A

AU - Fagnani, Corrado

AU - D'Ippolito, Cristina

AU - Freitas, Duarte L

AU - Maia, José Antonio

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Rebato, Esther

AU - Busjahn, Andreas

AU - Kandler, Christian

AU - Saudino, Kimberly J

AU - Jang, Kerry L

AU - Cozen, Wendy

AU - Hwang, Amie E

AU - Mack, Thomas M

AU - Gao, Wenjing

AU - Yu, Canqing

AU - Li, Liming

AU - Corley, Robin P

AU - Huibregtse, Brooke M

AU - Derom, Catherine A

AU - Vlietinck, Robert F

AU - Loos, Ruth J F

AU - Heikkilä, Kauko

AU - Wardle, Jane

AU - Llewellyn, Clare H

AU - Fisher, Abigail

AU - McAdams, Tom A

AU - Eley, Thalia C

AU - Gregory, Alice M

AU - He, Mingguang

AU - Ding, Xiaohu

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Tarnoki, Adam D

AU - Tarnoki, David L

AU - Knafo-Noam, Ariel

AU - Mankuta, David

AU - Abramson, Lior

AU - Burt, S Alexandra

AU - Klump, Kelly L

AU - Silberg, Judy L

AU - Eaves, Lindon J

AU - Maes, Hermine H

AU - Krueger, Robert F

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Gatz, Margaret

AU - Butler, David A

AU - Bartels, Meike

AU - van Beijsterveldt, Toos C E M

AU - Craig, Jeffrey M

AU - Saffery, Richard

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Martin, Nicholas G

AU - Medland, Sarah E

AU - Montgomery, Grant W

AU - Swan, Gary E

AU - Krasnow, Ruth

AU - Tynelius, Per

AU - Lichtenstein, Paul

AU - Haworth, Claire M A

AU - Plomin, Robert

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Harden, K Paige

AU - Tucker-Drob, Elliot M

AU - Spector, Timothy

AU - Mangino, Massimo

AU - Lachance, Genevieve

AU - Baker, Laura A

AU - Tuvblad, Catherine

AU - Duncan, Glen E

AU - Buchwald, Dedra

AU - Willemsen, Gonneke

AU - Skytthe, Axel

AU - Kyvik, Kirsten O

AU - Christensen, Kaare

AU - Öncel, Sevgi Y

AU - Aliev, Fazil

AU - Rasmussen, Finn

AU - Goldberg, Jack H

AU - Sørensen, Thorkild I A

AU - Boomsma, Dorret I

AU - Kaprio, Jaakko

AU - Silventoinen, Karri

PY - 2016

Y1 - 2016

N2 - Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

AB - Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

U2 - 10.1038/srep28496

DO - 10.1038/srep28496

M3 - Journal article

C2 - 27333805

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 28496

ER -