TY - JOUR
T1 - Genetic and environmental influences on cardiovascular risk factors and cognitive function
T2 - A Chinese twin aging study
AU - Xu, Chunsheng
AU - Tian, Xiaocao
AU - Sun, Jianping
AU - Wu, Yili
AU - Zhang, Dongfeng
AU - Pang, Zengchang
AU - Li, Shuxia
AU - Petersen, Inge
AU - Mengel-From, Jonas
AU - Christiansen, Lene
AU - Christensen, Kaare
AU - Tan, Qihua
N1 - © 2017 Japan Geriatrics Society.
PY - 2018/2
Y1 - 2018/2
N2 - Aim: To explore the genetic and environmental influences on cardiovascular risk factors (CVRF) and cognitive function in the world's largest and rapidly aging Chinese population. Methods: Cognitive function and CVRF, including body mass index, systolic blood pressure, diastolic blood pressure, pulse pressure, glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDLC) and low-density lipoprotein cholesterol were measured in 379 complete twin pairs. Univariate and bivariate twin models were fitted to estimate the genetic and environmental components in the variance and covariance of CVRF and cognition. Results: Mild-to-high heritability was estimated for CVRF and cognition (0.27–0.74). Unique environmental factors showed low-to-moderate contributions (0.23–0.56). Only HDLC presented significant common environmental contribution (0.50). Bivariate analysis showed significantly negative genetic correlations (r
G) between cognition and systolic blood pressure (r
G = −0.56), diastolic blood pressure (r
G = −0.42), pulse pressure (r
G = −0.45), and positive genetic correlations between cognition and total cholesterol (r
G = 0.33), triglyceride (r
G = 0.23) and HDLC (r
G = 0.41). HDLC and cognition presented a unique environmental correlation (r
E = −0.13), but in the opposite direction. Conclusions: Cognitive function was genetically related to systolic blood pressure, diastolic blood pressure, pulse pressure, total cholesterol, triglyceride and HDLC with a negative or positive direction. Cognition and HDLC might share part of a similar unique environmental factor. Geriatr Gerontol Int 2018; 18: 352–359.
AB - Aim: To explore the genetic and environmental influences on cardiovascular risk factors (CVRF) and cognitive function in the world's largest and rapidly aging Chinese population. Methods: Cognitive function and CVRF, including body mass index, systolic blood pressure, diastolic blood pressure, pulse pressure, glucose, total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDLC) and low-density lipoprotein cholesterol were measured in 379 complete twin pairs. Univariate and bivariate twin models were fitted to estimate the genetic and environmental components in the variance and covariance of CVRF and cognition. Results: Mild-to-high heritability was estimated for CVRF and cognition (0.27–0.74). Unique environmental factors showed low-to-moderate contributions (0.23–0.56). Only HDLC presented significant common environmental contribution (0.50). Bivariate analysis showed significantly negative genetic correlations (r
G) between cognition and systolic blood pressure (r
G = −0.56), diastolic blood pressure (r
G = −0.42), pulse pressure (r
G = −0.45), and positive genetic correlations between cognition and total cholesterol (r
G = 0.33), triglyceride (r
G = 0.23) and HDLC (r
G = 0.41). HDLC and cognition presented a unique environmental correlation (r
E = −0.13), but in the opposite direction. Conclusions: Cognitive function was genetically related to systolic blood pressure, diastolic blood pressure, pulse pressure, total cholesterol, triglyceride and HDLC with a negative or positive direction. Cognition and HDLC might share part of a similar unique environmental factor. Geriatr Gerontol Int 2018; 18: 352–359.
KW - cardiovascular risk factor
KW - classical twin design
KW - cognitive function
KW - genetic correlation
KW - heritability
KW - cardiovascular risk factor
KW - classical twin design
KW - cognitive function
KW - genetic correlation
KW - heritability
U2 - 10.1111/ggi.13161
DO - 10.1111/ggi.13161
M3 - Journal article
C2 - 28857473
VL - 18
SP - 352
EP - 359
JO - Geriatrics & Gerontology International
JF - Geriatrics & Gerontology International
SN - 1444-1586
IS - 2
ER -