Gastrointestinal stromatumor: Klinisk og patologisk præsentation

Translated title of the contribution: Gastro Intestinal Stromal Tumor--clinical and pathological presentation

Michael Bau Mortensen, Karl Egon Larsen, Claus Wilki Fristrup, Henning Overgaard Nielsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

INTRODUCTION: Gastrointestinal stromal tumor (GIST) is a rare mesenchymal tumor identified by a positive immunostaining (KIT tyrosine kinase). Surgical resection is the primary treatment, but non-resectable and recurrent disease may be treated by specific tyrosine kinase inhibitors. This study evaluates the clinical and pathological presentation of a Danish GIST population. MATERIALS AND METHODS: Retrospective evaluation of patients diagnosed, treated and/or followed under the GIST diagnosis at the Department of Surgery, Odense University Hospital, during the period from January 1995 to September 2006. RESULTS: 41 patients with GIST were identified (25 males, 16 females, median age 62 years). The predominant symptoms leading to the diagnosis were upper gastrointestinal bleeding and abdominal pain. The majority of tumors were located in the stomach (63%) or in the small intestine (22%). 95% of the patients had a complete surgical resection, whereas resection was impossible in 2 patients. Approximately (2)/3 of the patients had a low or medium risk of developing metastases according to tumor size and number of mitoses. 1 in 4 patients was treated with a tyrosine kinase inhibitor during the course of the disease. CONCLUSION: GIST is a rare mesenchymal tumor but due to immunostaining methods the detection rate is increasing. The clinical and pathological presentation of this Danish GIST population is comparable to international data.
Translated title of the contributionGastro Intestinal Stromal Tumor--clinical and pathological presentation
Original languageDanish
JournalUgeskrift for læger
Volume169
Issue number34
Pages (from-to)2776-2779
Number of pages3
ISSN0041-5782
Publication statusPublished - 20. Aug 2007

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents
  • Female
  • Follow-Up Studies
  • Gastrectomy
  • Gastrointestinal Stromal Tumors
  • Humans
  • Intestine, Small
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Retrospective Studies
  • Risk Factors

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