Frequency and heritability of depression symptomatology in the second half of life: Evidence from Danish twins over 45

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background. Self-reported depressive symptoms among the elderly have generated considerable interest because they are readily available measures of overall well-being in a population often thought to be at special risk for mental disorder.

Method. The heritability of depression symptoms was investigated in a sample of 2169 pairs of Danish twins (1033 MZ and 1136 same sex DZ) ranging in age from 45 to over 95. Twins completed an interview assessment that identified symptoms of depression, which were scored on Affective, Somatic and Total scales.

Results. Overall heritability estimates (a2) for the Affective (a2 = 0.27, (95% CI 0.22–0.32)). Somatic (a2 = 0.26, (0.21–0.32)), and Total (a2 = 0.29, (0.22–0.34)) scales were all moderate, statistically significant and similar to results from other studies. To assess possible variations in heritability across the wide age span, the sample was stratified into age groups in increments of 10 years. The magnitude of heritable influence did not vary significantly with age or sex. Somatic scale heritability tended to be greater for females than for males, though this difference was not statistically significant. The genetic correlation between the Affective and Somatic scales was 0.71, suggesting substantial common genetic origins.
Original languageEnglish
JournalPsychological Medicine
Volume32
Issue number7
Pages (from-to)1175-85
ISSN0033-2917
DOIs
Publication statusPublished - 2002

Fingerprint

Half-Life
Depression
Age Groups
Interviews
Population

Cite this

@article{5c3f09b0ba9911dc9626000ea68e967b,
title = "Frequency and heritability of depression symptomatology in the second half of life: Evidence from Danish twins over 45",
abstract = "Background. Self-reported depressive symptoms among the elderly have generated considerable interest because they are readily available measures of overall well-being in a population often thought to be at special risk for mental disorder.Method. The heritability of depression symptoms was investigated in a sample of 2169 pairs of Danish twins (1033 MZ and 1136 same sex DZ) ranging in age from 45 to over 95. Twins completed an interview assessment that identified symptoms of depression, which were scored on Affective, Somatic and Total scales.Results. Overall heritability estimates (a2) for the Affective (a2 = 0.27, (95{\%} CI 0.22–0.32)). Somatic (a2 = 0.26, (0.21–0.32)), and Total (a2 = 0.29, (0.22–0.34)) scales were all moderate, statistically significant and similar to results from other studies. To assess possible variations in heritability across the wide age span, the sample was stratified into age groups in increments of 10 years. The magnitude of heritable influence did not vary significantly with age or sex. Somatic scale heritability tended to be greater for females than for males, though this difference was not statistically significant. The genetic correlation between the Affective and Somatic scales was 0.71, suggesting substantial common genetic origins.",
author = "W. Johnson and M. McGue and D. Gaist and J.W. Vaupel and K. Christensen",
year = "2002",
doi = "10.1017/S0033291702006207",
language = "English",
volume = "32",
pages = "1175--85",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Heinemann",
number = "7",

}

Frequency and heritability of depression symptomatology in the second half of life : Evidence from Danish twins over 45. / Johnson, W.; McGue, M.; Gaist, D.; Vaupel, J.W.; Christensen, K.

In: Psychological Medicine, Vol. 32, No. 7, 2002, p. 1175-85.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Frequency and heritability of depression symptomatology in the second half of life

T2 - Evidence from Danish twins over 45

AU - Johnson, W.

AU - McGue, M.

AU - Gaist, D.

AU - Vaupel, J.W.

AU - Christensen, K.

PY - 2002

Y1 - 2002

N2 - Background. Self-reported depressive symptoms among the elderly have generated considerable interest because they are readily available measures of overall well-being in a population often thought to be at special risk for mental disorder.Method. The heritability of depression symptoms was investigated in a sample of 2169 pairs of Danish twins (1033 MZ and 1136 same sex DZ) ranging in age from 45 to over 95. Twins completed an interview assessment that identified symptoms of depression, which were scored on Affective, Somatic and Total scales.Results. Overall heritability estimates (a2) for the Affective (a2 = 0.27, (95% CI 0.22–0.32)). Somatic (a2 = 0.26, (0.21–0.32)), and Total (a2 = 0.29, (0.22–0.34)) scales were all moderate, statistically significant and similar to results from other studies. To assess possible variations in heritability across the wide age span, the sample was stratified into age groups in increments of 10 years. The magnitude of heritable influence did not vary significantly with age or sex. Somatic scale heritability tended to be greater for females than for males, though this difference was not statistically significant. The genetic correlation between the Affective and Somatic scales was 0.71, suggesting substantial common genetic origins.

AB - Background. Self-reported depressive symptoms among the elderly have generated considerable interest because they are readily available measures of overall well-being in a population often thought to be at special risk for mental disorder.Method. The heritability of depression symptoms was investigated in a sample of 2169 pairs of Danish twins (1033 MZ and 1136 same sex DZ) ranging in age from 45 to over 95. Twins completed an interview assessment that identified symptoms of depression, which were scored on Affective, Somatic and Total scales.Results. Overall heritability estimates (a2) for the Affective (a2 = 0.27, (95% CI 0.22–0.32)). Somatic (a2 = 0.26, (0.21–0.32)), and Total (a2 = 0.29, (0.22–0.34)) scales were all moderate, statistically significant and similar to results from other studies. To assess possible variations in heritability across the wide age span, the sample was stratified into age groups in increments of 10 years. The magnitude of heritable influence did not vary significantly with age or sex. Somatic scale heritability tended to be greater for females than for males, though this difference was not statistically significant. The genetic correlation between the Affective and Somatic scales was 0.71, suggesting substantial common genetic origins.

U2 - 10.1017/S0033291702006207

DO - 10.1017/S0033291702006207

M3 - Journal article

VL - 32

SP - 1175

EP - 1185

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 7

ER -