Four days of muscle disuse impairs single fiber contractile function in young and old healthy men

Lars Grøndahl Hvid, Charlotte Arneboe Suetta, Per Aagaard, Michael Kjaer, Ulrik Frandsen, Niels Ortenblad

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The purpose of the study was to investigate the effects of 4 days of disuse (knee brace) on contractile function of isolated vastus lateralis fibers (n=486) from 11 young (24.3+/-0.9 yrs) and 11 old (67.2+/-1.0 yrs) healthy men having comparable levels of physical activity. Prior to disuse single fiber specific force (maximal Ca(2+)-activated force per cross-sectional area) was lower in MHC I vs. IIa fibers (p
Original languageEnglish
JournalExperimental Gerontology
Volume48
Issue number2
Pages (from-to)154–161
ISSN0531-5565
DOIs
Publication statusPublished - 2013

Keywords

  • Adult Age Factors Aged Braces Calcium/metabolism Denmark Humans *Immobilization/instrumentation *Isometric Contraction Linear Models Male *Muscle Fibers, Skeletal/metabolism Muscle Strength Muscular Atrophy/etiology/metabolism/*physiopathology Myosin Heavy Chains/metabolism Protein Isoforms Quadriceps Muscle/metabolism/*physiopathology Time Factors Young Adult

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