Fibrinolytic Changes in Women with Preeclampsia

Anne Cathrine Godtfredsen*, Johannes Jakobsen Sidelmann, Britta Blume Dolleris, Jan Stener Jørgensen, Emma Kathrine Jungjohan Johansen, Melissa Fernard Bøg Pedersen, Yaseelan Palarasah, Jørgen Brodersen Gram

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

OBJECTIVES: Preeclampsia (PE) is a serious complication of pregnancy. The fibrinolytic system play crucial roles regarding placentation and evolution of PE.

AIM: To study comprehensively components of the fibrinolytic system and fibrin lysability in women with PE.

DESIGN AND METHODS: 117 women with PE and matched controls were included. Tissue type plasminogen activator (t-PA), plasminogen, PAI-1, plasmin inhibitor (PI), D-dimer, the fibrinolytic potential of dextran sulphate euglobulin fraction (DEF), PAI-2, polymere PAI-2, fibrin clot lysability, thrombin activatable fibrinolysis inhibitor (TAFI) and fibrinogen were assessed.

RESULTS: Women with PE had significantly increased concentrations of t-PA and PAI-1, whereas the plasma concentration of PAI-2 was significantly lower compared to controls, p < 0.0001. Polymere PAI-2 was detected in both groups. DEF, TAFI and fibrinogen were not different between the groups. D-dimer was significantly increased and plasminogen/PI together with fibrin clot lysability time decreased in the PE-group, p  =  0.0004 p  =  0.04, p  =  0.03, p < 0.0001 respectively.

CONCLUSION: This study demonstrates that PE is associated with an affected t-PA/PAI-1 system, decreased PAI-2 and increased fibrin lysability. Furthermore, PAI-2 has the potential to polymerize during pregnancy.

Original languageEnglish
JournalClinical and Applied Thrombosis/Hemostasis
Volume28
Pages (from-to)1-8
ISSN1076-0296
DOIs
Publication statusPublished - 2022

Keywords

  • PAI-2
  • fibrin lysability
  • fibrinolysis
  • preeclampsia
  • protein polymerization

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