Fetal growth in pregnancies conceived after gastric bypass surgery in relation to surgery-to-conception interval

a Danish national cohort study

Lone Nikoline Nørgaard, Anne Cathrine Roslev Gjerris, Ida Kirkegaard, Janne Foss Berlac, Ann Tabor, Danish Fetal Medicine Research Group, Lene Sperling

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: To describe early and late fetal growth in pregnancies conceived after gastric bypass surgery in relation to time from surgery to conception of pregnancy.

METHODS: National cohort study on 387 Danish women, who had laparoscopic or open gastric bypass surgery prior to a singleton pregnancy in which first trimester screening was performed between January 2008 and June 2011. Data were derived from national registers (Danish National Registry of Patients and Danish National Birth Registry, Pregnancy Complications and Abortion-clinical quality database (PreCAb) and the Danish Fetal Medicine Database). Main outcome measures were early and late fetal growth in relation to time from bariatric surgery to conception of the pregnancy. Early fetal growth was expressed as "Fetal Growth Index": the ratio between the estimated number of days from first trimester ultrasound to second trimester ultrasound biometries and the actual calender time elapsed in days. Late fetal growth was expressed as the observed versus expected birthweight according to gestational age (GA).

RESULTS: The surgery-to-conception interval ranged from 3 to 1851 days with a mean value of 502 (SD, 351) days. The mean "fetal growth index" was 0.99 (SD, 0.02) days/day and thus significantly lower than in the background population (mean, 1.04 (SD, 0.09) days/day, p<0.0001). The proportion of infants being small for gestational age was 18.8% and the proportion of large for gestational age infants was 6.7%. The correlation coefficients between surgery-to-conception time and "fetal growth index" and birthweight according to GA were 0.01 (p = 0.8) and 0.04 (p = 0.4), respectively.

CONCLUSION: Fetal growth index was lower than reported in the background population. No correlation was found between the surgery-to-conception interval and early or late fetal growth in pregnancies conceived after gastric bypass surgery.

Original languageEnglish
Article numbere90317
JournalPLOS ONE
Volume9
Issue number3
ISSN1932-6203
DOIs
Publication statusPublished - 2014

Fingerprint

bariatric surgery
Gastric Bypass
fetal development
cohort studies
Surgery
Cohort Studies
surgery
pregnancy
Gestational Age
gestational age
First Pregnancy Trimester
birth weight
Registries
Ultrasonics
pregnancy complications
small for gestational age
Databases
Small for Gestational Age Infant
Calenders
abortion (animals)

Keywords

  • Adult
  • Birth Weight
  • Cohort Studies
  • Female
  • Fetal Development
  • Gastric Bypass
  • Gestational Age
  • Humans
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Outcome
  • Time Factors

Cite this

Nørgaard, L. N., Gjerris, A. C. R., Kirkegaard, I., Berlac, J. F., Tabor, A., Danish Fetal Medicine Research Group, & Sperling, L. (2014). Fetal growth in pregnancies conceived after gastric bypass surgery in relation to surgery-to-conception interval: a Danish national cohort study. PLOS ONE, 9(3), [e90317]. https://doi.org/10.1371/journal.pone.0090317
Nørgaard, Lone Nikoline ; Gjerris, Anne Cathrine Roslev ; Kirkegaard, Ida ; Berlac, Janne Foss ; Tabor, Ann ; Danish Fetal Medicine Research Group ; Sperling, Lene . / Fetal growth in pregnancies conceived after gastric bypass surgery in relation to surgery-to-conception interval : a Danish national cohort study. In: PLOS ONE. 2014 ; Vol. 9, No. 3.
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abstract = "OBJECTIVE: To describe early and late fetal growth in pregnancies conceived after gastric bypass surgery in relation to time from surgery to conception of pregnancy.METHODS: National cohort study on 387 Danish women, who had laparoscopic or open gastric bypass surgery prior to a singleton pregnancy in which first trimester screening was performed between January 2008 and June 2011. Data were derived from national registers (Danish National Registry of Patients and Danish National Birth Registry, Pregnancy Complications and Abortion-clinical quality database (PreCAb) and the Danish Fetal Medicine Database). Main outcome measures were early and late fetal growth in relation to time from bariatric surgery to conception of the pregnancy. Early fetal growth was expressed as {"}Fetal Growth Index{"}: the ratio between the estimated number of days from first trimester ultrasound to second trimester ultrasound biometries and the actual calender time elapsed in days. Late fetal growth was expressed as the observed versus expected birthweight according to gestational age (GA).RESULTS: The surgery-to-conception interval ranged from 3 to 1851 days with a mean value of 502 (SD, 351) days. The mean {"}fetal growth index{"} was 0.99 (SD, 0.02) days/day and thus significantly lower than in the background population (mean, 1.04 (SD, 0.09) days/day, p<0.0001). The proportion of infants being small for gestational age was 18.8{\%} and the proportion of large for gestational age infants was 6.7{\%}. The correlation coefficients between surgery-to-conception time and {"}fetal growth index{"} and birthweight according to GA were 0.01 (p = 0.8) and 0.04 (p = 0.4), respectively.CONCLUSION: Fetal growth index was lower than reported in the background population. No correlation was found between the surgery-to-conception interval and early or late fetal growth in pregnancies conceived after gastric bypass surgery.",
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Fetal growth in pregnancies conceived after gastric bypass surgery in relation to surgery-to-conception interval : a Danish national cohort study. / Nørgaard, Lone Nikoline; Gjerris, Anne Cathrine Roslev; Kirkegaard, Ida; Berlac, Janne Foss; Tabor, Ann; Danish Fetal Medicine Research Group ; Sperling, Lene .

In: PLOS ONE, Vol. 9, No. 3, e90317, 2014.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Fetal growth in pregnancies conceived after gastric bypass surgery in relation to surgery-to-conception interval

T2 - a Danish national cohort study

AU - Nørgaard, Lone Nikoline

AU - Gjerris, Anne Cathrine Roslev

AU - Kirkegaard, Ida

AU - Berlac, Janne Foss

AU - Tabor, Ann

AU - Danish Fetal Medicine Research Group

AU - Sperling, Lene

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: To describe early and late fetal growth in pregnancies conceived after gastric bypass surgery in relation to time from surgery to conception of pregnancy.METHODS: National cohort study on 387 Danish women, who had laparoscopic or open gastric bypass surgery prior to a singleton pregnancy in which first trimester screening was performed between January 2008 and June 2011. Data were derived from national registers (Danish National Registry of Patients and Danish National Birth Registry, Pregnancy Complications and Abortion-clinical quality database (PreCAb) and the Danish Fetal Medicine Database). Main outcome measures were early and late fetal growth in relation to time from bariatric surgery to conception of the pregnancy. Early fetal growth was expressed as "Fetal Growth Index": the ratio between the estimated number of days from first trimester ultrasound to second trimester ultrasound biometries and the actual calender time elapsed in days. Late fetal growth was expressed as the observed versus expected birthweight according to gestational age (GA).RESULTS: The surgery-to-conception interval ranged from 3 to 1851 days with a mean value of 502 (SD, 351) days. The mean "fetal growth index" was 0.99 (SD, 0.02) days/day and thus significantly lower than in the background population (mean, 1.04 (SD, 0.09) days/day, p<0.0001). The proportion of infants being small for gestational age was 18.8% and the proportion of large for gestational age infants was 6.7%. The correlation coefficients between surgery-to-conception time and "fetal growth index" and birthweight according to GA were 0.01 (p = 0.8) and 0.04 (p = 0.4), respectively.CONCLUSION: Fetal growth index was lower than reported in the background population. No correlation was found between the surgery-to-conception interval and early or late fetal growth in pregnancies conceived after gastric bypass surgery.

AB - OBJECTIVE: To describe early and late fetal growth in pregnancies conceived after gastric bypass surgery in relation to time from surgery to conception of pregnancy.METHODS: National cohort study on 387 Danish women, who had laparoscopic or open gastric bypass surgery prior to a singleton pregnancy in which first trimester screening was performed between January 2008 and June 2011. Data were derived from national registers (Danish National Registry of Patients and Danish National Birth Registry, Pregnancy Complications and Abortion-clinical quality database (PreCAb) and the Danish Fetal Medicine Database). Main outcome measures were early and late fetal growth in relation to time from bariatric surgery to conception of the pregnancy. Early fetal growth was expressed as "Fetal Growth Index": the ratio between the estimated number of days from first trimester ultrasound to second trimester ultrasound biometries and the actual calender time elapsed in days. Late fetal growth was expressed as the observed versus expected birthweight according to gestational age (GA).RESULTS: The surgery-to-conception interval ranged from 3 to 1851 days with a mean value of 502 (SD, 351) days. The mean "fetal growth index" was 0.99 (SD, 0.02) days/day and thus significantly lower than in the background population (mean, 1.04 (SD, 0.09) days/day, p<0.0001). The proportion of infants being small for gestational age was 18.8% and the proportion of large for gestational age infants was 6.7%. The correlation coefficients between surgery-to-conception time and "fetal growth index" and birthweight according to GA were 0.01 (p = 0.8) and 0.04 (p = 0.4), respectively.CONCLUSION: Fetal growth index was lower than reported in the background population. No correlation was found between the surgery-to-conception interval and early or late fetal growth in pregnancies conceived after gastric bypass surgery.

KW - Adult

KW - Birth Weight

KW - Cohort Studies

KW - Female

KW - Fetal Development

KW - Gastric Bypass

KW - Gestational Age

KW - Humans

KW - Pregnancy

KW - Pregnancy Complications

KW - Pregnancy Outcome

KW - Time Factors

U2 - 10.1371/journal.pone.0090317

DO - 10.1371/journal.pone.0090317

M3 - Journal article

VL - 9

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 3

M1 - e90317

ER -