Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells

Charlotte Harken Jensen, K Erb, L G Westergaard, A Kliem, B Teisner

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Fetal antigen 1 (FA1), an epidermal growth factor (EGF) multidomain glycoprotein, was investigated in the human reproductive system. Immunohistochemical analysis of the male reproductive system revealed staining for FA1 in the Leydig cells only. Concentrations of FA1 in seminal plasma and serum were similar and significantly correlated in weekly samples from three men (P < 0.0065). The concentrations in seminal plasma from vasectomized men (n = 4) were not significantly different from those of normal men (n = 187). The concentration of FA1 in seminal plasma was significantly correlated with the sperm counts of normozoospermic men (P < 0.0001), and significantly higher in seminal plasma from men with sperm counts > 20 x 10(6)/ml, compared with those with counts
Udgivelsesdato: 1999-Oct
Original languageEnglish
JournalMolecular Human Reproduction
Volume5
Issue number10
Pages (from-to)908-13
Number of pages5
ISSN1360-9947
Publication statusPublished - 1. Oct 1999

Keywords

  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Epidermal Growth Factor
  • Female
  • Follicular Fluid
  • Glycoproteins
  • Gonadal Steroid Hormones
  • Humans
  • Immunohistochemistry
  • Male
  • Ovary
  • Reproduction
  • Semen
  • Spermatozoa
  • Testis

Cite this

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title = "Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells",
abstract = "Fetal antigen 1 (FA1), an epidermal growth factor (EGF) multidomain glycoprotein, was investigated in the human reproductive system. Immunohistochemical analysis of the male reproductive system revealed staining for FA1 in the Leydig cells only. Concentrations of FA1 in seminal plasma and serum were similar and significantly correlated in weekly samples from three men (P < 0.0065). The concentrations in seminal plasma from vasectomized men (n = 4) were not significantly different from those of normal men (n = 187). The concentration of FA1 in seminal plasma was significantly correlated with the sperm counts of normozoospermic men (P < 0.0001), and significantly higher in seminal plasma from men with sperm counts > 20 x 10(6)/ml, compared with those with counts Udgivelsesdato: 1999-Oct",
keywords = "Adult, Enzyme-Linked Immunosorbent Assay, Epidermal Growth Factor, Female, Follicular Fluid, Glycoproteins, Gonadal Steroid Hormones, Humans, Immunohistochemistry, Male, Ovary, Reproduction, Semen, Spermatozoa, Testis",
author = "Jensen, {Charlotte Harken} and K Erb and Westergaard, {L G} and A Kliem and B Teisner",
year = "1999",
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language = "English",
volume = "5",
pages = "908--13",
journal = "Molecular Human Reproduction",
issn = "1360-9947",
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Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells. / Jensen, Charlotte Harken; Erb, K; Westergaard, L G; Kliem, A; Teisner, B.

In: Molecular Human Reproduction, Vol. 5, No. 10, 01.10.1999, p. 908-13.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Fetal antigen 1, an EGF multidomain protein in the sex hormone-producing cells of the gonads and the microenvironment of germ cells

AU - Jensen, Charlotte Harken

AU - Erb, K

AU - Westergaard, L G

AU - Kliem, A

AU - Teisner, B

PY - 1999/10/1

Y1 - 1999/10/1

N2 - Fetal antigen 1 (FA1), an epidermal growth factor (EGF) multidomain glycoprotein, was investigated in the human reproductive system. Immunohistochemical analysis of the male reproductive system revealed staining for FA1 in the Leydig cells only. Concentrations of FA1 in seminal plasma and serum were similar and significantly correlated in weekly samples from three men (P < 0.0065). The concentrations in seminal plasma from vasectomized men (n = 4) were not significantly different from those of normal men (n = 187). The concentration of FA1 in seminal plasma was significantly correlated with the sperm counts of normozoospermic men (P < 0.0001), and significantly higher in seminal plasma from men with sperm counts > 20 x 10(6)/ml, compared with those with counts Udgivelsesdato: 1999-Oct

AB - Fetal antigen 1 (FA1), an epidermal growth factor (EGF) multidomain glycoprotein, was investigated in the human reproductive system. Immunohistochemical analysis of the male reproductive system revealed staining for FA1 in the Leydig cells only. Concentrations of FA1 in seminal plasma and serum were similar and significantly correlated in weekly samples from three men (P < 0.0065). The concentrations in seminal plasma from vasectomized men (n = 4) were not significantly different from those of normal men (n = 187). The concentration of FA1 in seminal plasma was significantly correlated with the sperm counts of normozoospermic men (P < 0.0001), and significantly higher in seminal plasma from men with sperm counts > 20 x 10(6)/ml, compared with those with counts Udgivelsesdato: 1999-Oct

KW - Adult

KW - Enzyme-Linked Immunosorbent Assay

KW - Epidermal Growth Factor

KW - Female

KW - Follicular Fluid

KW - Glycoproteins

KW - Gonadal Steroid Hormones

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Ovary

KW - Reproduction

KW - Semen

KW - Spermatozoa

KW - Testis

M3 - Journal article

VL - 5

SP - 908

EP - 913

JO - Molecular Human Reproduction

JF - Molecular Human Reproduction

SN - 1360-9947

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ER -