Feasibility and Safety of Laparoscopic D2 Gastrectomy in Combination with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Gastric Cancer at High Risk of Recurrence-The PIPAC-OPC4 Study

Martin Graversen, I Rouvelas, A P Ainsworth, A P Bjarnesen, S Detlefsen, S B Ellebaek, C W Fristrup, M G Liljefors, L Lundell, M Nilsson, P Pfeiffer, L S Tarpgaard, A Tsekrekos, M B Mortensen

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Abstract

BACKGROUND: Patients with gastric adenocarcinoma (GAC) are at high risk of peritoneal recurrence despite perioperative chemotherapy and radical resection. This study evaluated feasibility and safety of laparoscopic D2 gastrectomy in combination with pressurized intraperitoneal aerosol chemotherapy (PIPAC).

METHODS: This was a prospective, controlled bi-institutional study in patients with GAC at high risk of recurrence treated with PIPAC with cisplatin and doxorubicin (PIPAC C/D) after laparoscopic D2 gastrectomy. High risk was defined as a poorly cohesive subtype with predominance of signet-ring cells, clinical stage ≥ T3 and/or ≥ N2, or positive peritoneal cytology. Peritoneal lavage fluid was collected before and after resection. Cisplatin (10.5 mg/m 2) and doxorubicin (2.1 mg/m 2) were aerosolized after anastomosis (flow 0.5-0.8 ml/s, maximum pressure 300 PSI). Treatment was feasible and safe if ≤ 20% had Dindo-Clavien ≥ 3b surgical complications or CTCAE ≥ 4 medical adverse events within 30 days. Secondary outcomes were length of stay (LOS), peritoneal lavage cytology, and completion of postoperative systemic chemotherapy.

RESULTS: Twenty-one patients were treated with a D2 gastrectomy and PIPAC C/D. The median age was 61 years (range 24-76), there were eleven female patients, and 20 patients had preoperative chemotherapy. There was no mortality. Two patients had grade 3b complications that were potentially related to PIPAC C/D (one anastomotic leakage, and one late duodenal blow-out). One patient had severe neutropenia, and nine patients had moderate pain. The LOS was 6 days (4-26). One patient had positive peritoneal lavage cytology before resection, and none were positive after. Fifteen patients had postoperative chemotherapy.

CONCLUSIONS: Laparoscopic D2 gastrectomy in combination with PIPAC C/D is feasible and safe.

Original languageEnglish
JournalAnnals of Surgical Oncology
Volume30
Issue number7
Pages (from-to)4433-4441
ISSN1068-9265
DOIs
Publication statusPublished - Jul 2023

Keywords

  • Adult
  • Aerosols
  • Aged
  • Cisplatin
  • Doxorubicin
  • Feasibility Studies
  • Female
  • Humans
  • Laparoscopy
  • Middle Aged
  • Peritoneal Neoplasms/drug therapy
  • Prospective Studies
  • Stomach Neoplasms/drug therapy
  • Young Adult

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