Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

Sine Knorr, Birgitte Bytoft, Zuzana Lohse, Anne B Boisen, Tine D Clausen, Rikke B Jensen, Peter Damm, Henning Beck-Nielsen, Jens J Holst, Bolette Hartmann, Holger J Møller, Kurt Højlund, Claus H Gravholt, Dorte M Jensen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

OBJECTIVE: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and risk of fatty liver.

RESEARCH DESIGN AND METHODS: This study was a prospective nationwide follow-up study of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.

RESULTS: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.

CONCLUSIONS: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.

Original languageEnglish
JournalDiabetes Care
Volume42
Issue number8
Pages (from-to)1560-1568
ISSN0149-5992
DOIs
Publication statusPublished - Aug 2019

Fingerprint

Fatty Liver
Mothers
Maternal Exposure
Insulin Resistance
Macrophage Activation
Adiponectin
Leptin
HDL Cholesterol
Gestational Age
Insulin
Liver

Cite this

Knorr, S., Bytoft, B., Lohse, Z., Boisen, A. B., Clausen, T. D., Jensen, R. B., ... Jensen, D. M. (2019). Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study). Diabetes Care, 42(8), 1560-1568. https://doi.org/10.2337/dc19-0571
Knorr, Sine ; Bytoft, Birgitte ; Lohse, Zuzana ; Boisen, Anne B ; Clausen, Tine D ; Jensen, Rikke B ; Damm, Peter ; Beck-Nielsen, Henning ; Holst, Jens J ; Hartmann, Bolette ; Møller, Holger J ; Højlund, Kurt ; Gravholt, Claus H ; Jensen, Dorte M. / Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study). In: Diabetes Care. 2019 ; Vol. 42, No. 8. pp. 1560-1568.
@article{a2451ddbc9bb43309bd6c0959a7d3223,
title = "Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)",
abstract = "OBJECTIVE: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and risk of fatty liver.RESEARCH DESIGN AND METHODS: This study was a prospective nationwide follow-up study of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.RESULTS: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.CONCLUSIONS: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.",
author = "Sine Knorr and Birgitte Bytoft and Zuzana Lohse and Boisen, {Anne B} and Clausen, {Tine D} and Jensen, {Rikke B} and Peter Damm and Henning Beck-Nielsen and Holst, {Jens J} and Bolette Hartmann and M{\o}ller, {Holger J} and Kurt H{\o}jlund and Gravholt, {Claus H} and Jensen, {Dorte M}",
note = "{\circledC} 2019 by the American Diabetes Association.",
year = "2019",
month = "8",
doi = "10.2337/dc19-0571",
language = "English",
volume = "42",
pages = "1560--1568",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "8",

}

Knorr, S, Bytoft, B, Lohse, Z, Boisen, AB, Clausen, TD, Jensen, RB, Damm, P, Beck-Nielsen, H, Holst, JJ, Hartmann, B, Møller, HJ, Højlund, K, Gravholt, CH & Jensen, DM 2019, 'Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)', Diabetes Care, vol. 42, no. 8, pp. 1560-1568. https://doi.org/10.2337/dc19-0571

Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study). / Knorr, Sine; Bytoft, Birgitte; Lohse, Zuzana; Boisen, Anne B; Clausen, Tine D; Jensen, Rikke B; Damm, Peter; Beck-Nielsen, Henning; Holst, Jens J; Hartmann, Bolette; Møller, Holger J; Højlund, Kurt; Gravholt, Claus H; Jensen, Dorte M.

In: Diabetes Care, Vol. 42, No. 8, 08.2019, p. 1560-1568.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

AU - Knorr, Sine

AU - Bytoft, Birgitte

AU - Lohse, Zuzana

AU - Boisen, Anne B

AU - Clausen, Tine D

AU - Jensen, Rikke B

AU - Damm, Peter

AU - Beck-Nielsen, Henning

AU - Holst, Jens J

AU - Hartmann, Bolette

AU - Møller, Holger J

AU - Højlund, Kurt

AU - Gravholt, Claus H

AU - Jensen, Dorte M

N1 - © 2019 by the American Diabetes Association.

PY - 2019/8

Y1 - 2019/8

N2 - OBJECTIVE: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and risk of fatty liver.RESEARCH DESIGN AND METHODS: This study was a prospective nationwide follow-up study of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.RESULTS: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.CONCLUSIONS: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.

AB - OBJECTIVE: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and risk of fatty liver.RESEARCH DESIGN AND METHODS: This study was a prospective nationwide follow-up study of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.RESULTS: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.CONCLUSIONS: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.

U2 - 10.2337/dc19-0571

DO - 10.2337/dc19-0571

M3 - Journal article

VL - 42

SP - 1560

EP - 1568

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 8

ER -

Knorr S, Bytoft B, Lohse Z, Boisen AB, Clausen TD, Jensen RB et al. Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study). Diabetes Care. 2019 Aug;42(8):1560-1568. https://doi.org/10.2337/dc19-0571