Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts

Karri Silventoinen, Jacob Hjelmborg, Sören Möller, Samuli Ripatti, Axel Skytthe, Emmi Tikkanen, Nancy L Pedersen, Patrik KE Magnusson, Kaare Christensen, Jaakko Kaprio

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.

Original languageEnglish
JournalInternational Journal of Epidemiology
Volume46
Issue number4
Pages (from-to)1223-1229
ISSN0300-5771
DOIs
Publication statusPublished - 1. Jan 2017

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Prospective Studies
Odds Ratio
Confidence Intervals
Dizygotic Twins
Monozygotic Twins
Denmark
Finland
Cluster Analysis

Keywords

  • Coronary heart disease
  • Stroke
  • Genetics
  • Twins
  • Family history

Cite this

Silventoinen, Karri ; Hjelmborg, Jacob ; Möller, Sören ; Ripatti, Samuli ; Skytthe, Axel ; Tikkanen, Emmi ; Pedersen, Nancy L ; Magnusson, Patrik KE ; Christensen, Kaare ; Kaprio, Jaakko. / Family aggregation of cardiovascular disease mortality : a register-based prospective study of pooled Nordic twin cohorts. In: International Journal of Epidemiology. 2017 ; Vol. 46, No. 4. pp. 1223-1229.
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abstract = "Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95{\%} confidence intervals (95{\%} CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95{\%} CI 1.40-1.57) for CHD and 1.81 for any stroke (95{\%} CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95{\%} CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.",
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Family aggregation of cardiovascular disease mortality : a register-based prospective study of pooled Nordic twin cohorts. / Silventoinen, Karri; Hjelmborg, Jacob; Möller, Sören; Ripatti, Samuli; Skytthe, Axel; Tikkanen, Emmi; Pedersen, Nancy L; Magnusson, Patrik KE; Christensen, Kaare; Kaprio, Jaakko.

In: International Journal of Epidemiology, Vol. 46, No. 4, 01.01.2017, p. 1223-1229.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Family aggregation of cardiovascular disease mortality

T2 - a register-based prospective study of pooled Nordic twin cohorts

AU - Silventoinen, Karri

AU - Hjelmborg, Jacob

AU - Möller, Sören

AU - Ripatti, Samuli

AU - Skytthe, Axel

AU - Tikkanen, Emmi

AU - Pedersen, Nancy L

AU - Magnusson, Patrik KE

AU - Christensen, Kaare

AU - Kaprio, Jaakko

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.

AB - Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.

KW - Coronary heart disease

KW - Stroke

KW - Genetics

KW - Twins

KW - Family history

U2 - 10.1093/ije/dyx012

DO - 10.1093/ije/dyx012

M3 - Journal article

C2 - 28338862

VL - 46

SP - 1223

EP - 1229

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 4

ER -