Factor VII-activating protease: sex-related association with coronary artery calcification

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

: Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1-99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4%, 81.1%, 0.84, respectively) compared with men (87.5%, 68.7%, 0.79, respectively) (P < 0.001). In women, total FSAP was significantly different between (3) Agatston score (111.5%) and (1) Agatston score (95.4%), respectively, (2) Agatston score (96.8%), (P < 0.05). Also, the specific activity of FSAP was significantly different between (3) Agatston score (0.77) and (1) Agatston score (0.85), respectively, (2) Agatston score [0.86 (0.86)] (P < 0.05). No difference in FSAP measures was observed in men. FSAP measures are higher in women compared with age-matched men. The extent of CAC in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.

Original languageEnglish
JournalBlood Coagulation and Fibrinolysis
Volume28
Issue number7
Pages (from-to)558-563
ISSN0957-5235
DOIs
Publication statusPublished - 2017

Fingerprint

Peptide Hydrolases
Urokinase-Type Plasminogen Activator
Sex Characteristics
Population
Diabetes Mellitus
Proteins

Keywords

  • Journal Article

Cite this

@article{d8e1a1885d5547e0bcecaa65259e9c12,
title = "Factor VII-activating protease: sex-related association with coronary artery calcification",
abstract = ": Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1-99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4{\%}, 81.1{\%}, 0.84, respectively) compared with men (87.5{\%}, 68.7{\%}, 0.79, respectively) (P < 0.001). In women, total FSAP was significantly different between (3) Agatston score (111.5{\%}) and (1) Agatston score (95.4{\%}), respectively, (2) Agatston score (96.8{\%}), (P < 0.05). Also, the specific activity of FSAP was significantly different between (3) Agatston score (0.77) and (1) Agatston score (0.85), respectively, (2) Agatston score [0.86 (0.86)] (P < 0.05). No difference in FSAP measures was observed in men. FSAP measures are higher in women compared with age-matched men. The extent of CAC in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.",
keywords = "Journal Article",
author = "Ramshanker Ramanathan and Gram, {J{\o}rgen B} and Sand, {Niels Peter R} and N{\o}rgaard, {Bjarne L} and Diederichsen, {Axel C P} and Frank Vitzthum and Herbert Schwarz and Sidelmann, {Johannes J}",
year = "2017",
doi = "10.1097/MBC.0000000000000640",
language = "English",
volume = "28",
pages = "558--563",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams & Wilkins",
number = "7",

}

Factor VII-activating protease : sex-related association with coronary artery calcification. / Ramanathan, Ramshanker; Gram, Jørgen B; Sand, Niels Peter R; Nørgaard, Bjarne L; Diederichsen, Axel C P; Vitzthum, Frank; Schwarz, Herbert; Sidelmann, Johannes J.

In: Blood Coagulation and Fibrinolysis, Vol. 28, No. 7, 2017, p. 558-563.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Factor VII-activating protease

T2 - sex-related association with coronary artery calcification

AU - Ramanathan, Ramshanker

AU - Gram, Jørgen B

AU - Sand, Niels Peter R

AU - Nørgaard, Bjarne L

AU - Diederichsen, Axel C P

AU - Vitzthum, Frank

AU - Schwarz, Herbert

AU - Sidelmann, Johannes J

PY - 2017

Y1 - 2017

N2 - : Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1-99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4%, 81.1%, 0.84, respectively) compared with men (87.5%, 68.7%, 0.79, respectively) (P < 0.001). In women, total FSAP was significantly different between (3) Agatston score (111.5%) and (1) Agatston score (95.4%), respectively, (2) Agatston score (96.8%), (P < 0.05). Also, the specific activity of FSAP was significantly different between (3) Agatston score (0.77) and (1) Agatston score (0.85), respectively, (2) Agatston score [0.86 (0.86)] (P < 0.05). No difference in FSAP measures was observed in men. FSAP measures are higher in women compared with age-matched men. The extent of CAC in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.

AB - : Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing the study population in three groups: (1) Agatston score = 0 U, (2) Agatston score = 1-99 U, or (3) Agatston score more than 99 U. A total of 134 women and 116 men were included. Total FSAP, FSAP GP, and specific FSAP activity were independently higher in women (97.4%, 81.1%, 0.84, respectively) compared with men (87.5%, 68.7%, 0.79, respectively) (P < 0.001). In women, total FSAP was significantly different between (3) Agatston score (111.5%) and (1) Agatston score (95.4%), respectively, (2) Agatston score (96.8%), (P < 0.05). Also, the specific activity of FSAP was significantly different between (3) Agatston score (0.77) and (1) Agatston score (0.85), respectively, (2) Agatston score [0.86 (0.86)] (P < 0.05). No difference in FSAP measures was observed in men. FSAP measures are higher in women compared with age-matched men. The extent of CAC in women is positively associated with total FSAP, but negatively associated with the specific activity of FSAP suggesting that FSAP may play a role in the evolution of CVD in women.

KW - Journal Article

U2 - 10.1097/MBC.0000000000000640

DO - 10.1097/MBC.0000000000000640

M3 - Journal article

C2 - 28548975

VL - 28

SP - 558

EP - 563

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 7

ER -