Extracellular matrix protein fibulin-1 plasma levels are associated with increased cardiovascular risk in chronic kidney disease

Research output: Contribution to conference without publisher/journalPosterResearch

Abstract

INTRODUCTION AND AIMS:
Fibulin-1 is one of the few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease in patients with chronic kidney disease.

METHODS:
Plasma fibulin-1 was determined in patients with chronic kidney disease (n=32; median age, 63 years; inter-quartile range, 51 to 73 years). Serological biomarkers related to cardiovascular disease (fibrinogen, interleukin 6, C-reactive protein) were measured. Arterial applanation tonometry was used to determine central hemodynamic and arterial stiffness indices.

RESULTS:
We observed a positive correlation of fibulin-1 levels with age (r=0.38; p=0.033), glycated hemoglobin (r=0.80; p=0.003), creatinine (r=0.35; p=0.045), and fibrinogen (r=0.39; p=0.027). Glomerular filtration rate and fibulin-1 were inversely correlated (r=-0.57; p=0.022). There was a positive correlation between fibulin-1 and central pulse pressure (r=0.44; p=0.011) and central augmentation pressure (r=0.55; p=0.001). In a multivariable regression model, diabetes, creatinine, fibrinogen and central augmentation pressure were independent predictors of plasma fibulin-1.

CONCLUSIONS:
Increased plasma fibulin-1 levels were associated with impaired kidney function and diabetes. Fibulin-1 levels were also associated with hemodynamic cardiovascular risk markers. We conclude, that fibulin-1 is involved in the pathogenesis of cardiovascular disease observed in chronic kidney disease.

Original languageEnglish
Publication date2013
Publication statusPublished - 2013
Event50th Congress European Renal Association (ERA) - Istanbul, Turkey
Duration: 18. May 201321. May 2013

Conference

Conference50th Congress European Renal Association (ERA)
CountryTurkey
CityIstanbul
Period18/05/201321/05/2013

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