Exploring ‘The autisms’ at a cognitive level

Cathriona Cantio, Jens Richardt M Jepsen, Gitte Madsen, Niels Bilenberg, Sarah White

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Abstract

The autism spectrum is characterized by genetic and behavioral heterogeneity. However, it is still unknown whether there is a universal pattern of cognitive impairment in autism spectrum disorder (ASD) and whether multiple cognitive impairments are needed to explain the full range of behavioral symptoms. This study aimed to determine whether three widely acknowledged cognitive abnormalities (Theory of Mind (ToM) impairment, Executive Function (EF) impairment, and the presence of a Local Processing Bias (LB)) are universal and fractionable in autism, and whether the relationship between cognition and behavior is dependent on the method of behavioral assessment. Thirty-one high-functioning children with ASD and thirty-seven children with neurotypical development (NTD), comparable in age, gender and Intelligence Quotient (IQ), completed several tasks tapping into ToM, EF, and LB, and autistic symptomatology was assessed through parental and teacher questionnaires, parental interview and direct observation. We found that ToM and EF deficits differentiated the groups and some ToM and EF tasks were related to each other. ToM and EF were together able to correctly classify more than three-quarters of the children into cases and controls, despite relating to none of the specific behavioral measures. Only a small subgroup of individuals displayed a LB, which was unrelated to ToM and EF, and did not aid diagnostic classification, most likely contributing to non-diagnostic symptoms in a subgroup. Despite the characteristic heterogeneity of the autism spectrum, it remains a possibility therefore that a single cognitive cause may underlie the range of diagnostic symptoms in all individuals with autism. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
Original languageEnglish
JournalAutism Research
Volume9
Issue number12
Pages (from-to)1328-1339
ISSN1939-3792
DOIs
Publication statusPublished - Dec 2016

Bibliographical note

This is the peer reviewed version of the following article: Cantio, C., Jepsen, J. R. M., Madsen, G. F., Bilenberg, N. and White, S. J. (2016), Exploring ‘The autisms’ at a cognitive level. Autism Research, 9: 1328–1339. doi:10.1002/aur.1630, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/aur.1630/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Keywords

  • Behavior
  • autism spectrum disorders
  • cognition
  • executive function
  • fractionation
  • local bias
  • symptomatology
  • theory of mind
  • Humans
  • Male
  • Cognition
  • Intelligence Tests
  • Denmark
  • Female
  • Theory of Mind
  • Autism Spectrum Disorder/complications
  • Child
  • Executive Function
  • Cognition Disorders/complications

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