Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles

Gisela Sjøgaard, Mette K Zebis, Kristian Kiilerich, Bengt Saltin, Henriette Pilegaard

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.
Original languageEnglish
Article number984523
JournalBioMed Research International
Volume2013
Number of pages12
ISSN2314-6133
DOIs
Publication statusPublished - 2013

Fingerprint

Resistance Training
Muscle
Heat-Shock Proteins
Exercise
Muscles
Messenger RNA
Superficial Back Muscles
Myalgia
Proteins
Carbohydrates
Oxidation
Biopsy
Growth
Metabolism
Randomized Controlled Trials
Cytokines

Cite this

Sjøgaard, Gisela ; Zebis, Mette K ; Kiilerich, Kristian ; Saltin, Bengt ; Pilegaard, Henriette. / Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles. In: BioMed Research International. 2013 ; Vol. 2013.
@article{eb42d1b03c1e409da72fe7034adf9ecf,
title = "Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles",
abstract = "The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.",
author = "Gisela Sj{\o}gaard and Zebis, {Mette K} and Kristian Kiilerich and Bengt Saltin and Henriette Pilegaard",
year = "2013",
doi = "10.1155/2013/984523",
language = "English",
volume = "2013",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles. / Sjøgaard, Gisela; Zebis, Mette K; Kiilerich, Kristian; Saltin, Bengt; Pilegaard, Henriette.

In: BioMed Research International, Vol. 2013, 984523, 2013.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles

AU - Sjøgaard, Gisela

AU - Zebis, Mette K

AU - Kiilerich, Kristian

AU - Saltin, Bengt

AU - Pilegaard, Henriette

PY - 2013

Y1 - 2013

N2 - The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.

AB - The aim was to assess mRNA and/or protein levels of heat shock proteins, cytokines, growth regulating, and metabolic proteins in myalgic muscle at rest and in response to work tasks and prolonged exercise training. A randomized controlled trial included 28 females with trapezius myalgia and 16 healthy controls. Those with myalgia performed ~7 hrs repetitive stressful work and were subsequently randomized to 10 weeks of specific strength training, general fitness training, or reference intervention. Muscles biopsies were taken from the trapezius muscle at baseline, after work and after 10 weeks intervention. The main findings are that the capacity of carbohydrate oxidation was reduced in myalgic compared with healthy muscle. Repetitive stressful work increased mRNA content for heat shock proteins and decreased levels of key regulators for growth and oxidative metabolism. In contrast, prolonged general fitness as well as specific strength training decreased mRNA content of heat shock protein while the capacity of carbohydrate oxidation was increased only after specific strength training.

U2 - 10.1155/2013/984523

DO - 10.1155/2013/984523

M3 - Journal article

C2 - 23509827

VL - 2013

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 984523

ER -