Evaluation of TRAF6 in a large multiancestral lupus cohort

Bahram Namjou, Chan-Bum Choi, Isaac T W Harley, Marta E Alarcón-Riquelme, Jennifer A Kelly, Stuart B Glenn, Joshua O Ojwang, Adam Adler, Kwangwoo Kim, Caroline J Gallant, Susan A Boackle, Lindsey A Criswell, Robert P Kimberly, Elizabeth E Brown, Jeffrey Edberg, Graciela S Alarcón, Anne M Stevens, Chaim O Jacob, Gary S Gilkeson, Diane L KamenBetty P Tsao, Juan-Manuel Anaya, Eun-Mi Kim, So-Yeon Park, Yoon-Kyoung Sung, Joel M Guthridge, Joan T Merrill, Michelle Petri, Rosalind Ramsey-Goldman, Luis M Vilá, Timothy B Niewold, Javier Martin, Bernardo A Pons-Estel, Timothy J Vyse, Barry I Freedman, Kathy L Moser, Patrick M Gaffney, Adrienne H Williams, Mary E Comeau, John D Reveille, Changwon Kang, Judith A James, R Hal Scofield, Carl D Langefeld, Kenneth M Kaufman, John B Harley, Sang-Cheol Bae, BIOLUPUS Network, Peter Junker, Anne Voss, Helle Laustrup

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with significant immune system aberrations resulting from complex heritable genetics as well as environmental factors. We undertook to study the role of TRAF6 as a candidate gene for SLE, since it plays a major role in several signaling pathways that are important for immunity and organ development.
Original languageEnglish
JournalArthritis & Rheumatism
Volume64
Issue number6
Pages (from-to)1960-9
Number of pages10
ISSN2326-5191
DOIs
Publication statusPublished - 2012

Keywords

  • Alleles
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Lupus Erythematosus, Systemic
  • Male
  • Polymorphism, Single Nucleotide
  • TNF Receptor-Associated Factor 6

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