Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

Basem M Abdallah, Anne-Christine Bay-Jensen, Bhuma Srinivasan, Nadine C Tabassi, Patrick Garnero, Jean-Marie Delaissé, Sundeep Khosla, Moustapha Kassem

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p 
Original languageEnglish
JournalJournal of Bone and Mineral Research
Volume26
Issue number10
Pages (from-to)2548-2551
ISSN0884-0431
DOIs
Publication statusPublished - 2011

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