Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors During the COVID-19 Epidemic in Denmark

Kathrine Agergård Kaspersen, Lotte Hindhede, Jens Kjærgaard Boldsen, Susan Mikkelsen, Lasse Skafte Vestergaard, Ann-Sofie Nicole Berthelsen, Ida Rask Moustsen-Helms, Dorte Kinggaard Holm, Anna Christine Nilsson, Susanne Gjørup Sækmose, Erik Sørensen, Lene Holm Harritshøj, Bitten Aagaard, Henrik Hjalgrim, Søren Thue Lillevang, Charlotte Sværke Jørgensen, Tyra Grove Krause, Henrik Ullum, Ole Birger Vestager Pedersen, Sisse Rye OstrowskiChristian Erikstrup

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality.

METHODS: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark.

RESULTS: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave.

CONCLUSIONS: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

Original languageEnglish
JournalThe Journal of Infectious Diseases
Volume225
Issue number2
Pages (from-to)219-228
ISSN0022-1899
DOIs
Publication statusPublished - 18. Jan 2022

Bibliographical note

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral/blood
  • Blood Donors
  • COVID-19/blood
  • Comorbidity
  • Denmark/epidemiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • SARS-CoV-2/isolation & purification
  • Seroepidemiologic Studies
  • Young Adult
  • blood donors
  • seroprevalence
  • SARS-CoV-2
  • infection fatality rate

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