Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand; Sheena Louise Forsberg; Mads Thomassen; Mirolyuba Ilieva; Morten Meyer; Åsa Fex Svenningsen; Tanja Maria Sheldrick-Michel

doi:10.1016/j.scr.2021.102185

Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Morad Kamand, Sheena Louise Forsberg, Mads Thomassen, Mirolyuba Ilieva, Morten Meyer, Åsa Fex Svenningsen, Tanja Maria Sheldrick-Michel

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.

Original language	English
Article number	102185
Journal	Stem Cell Research
Volume	51
ISSN	1873-5061
DOIs	https://doi.org/10.1016/j.scr.2021.102185
Publication status	Published - Mar 2021

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10.1016/j.scr.2021.102185Licence: CC BY-NC-ND

Open Access VersionFinal published version, 4.74 MBLicence: CC BY-NC-ND

1 Ph.D. thesis

Studying autism spectrum disorders (ASD) using a three-dimensional brain organoid model derived from patient-specific induced pluripotent stem cells (iPSCs): Autism from skin to brain
Kamand, M., 24. Jun 2022, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 225 p.
Research output: Thesis › Ph.D. thesis

Cite this

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title = "Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder",

abstract = "Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.",

author = "Morad Kamand and Forsberg, {Sheena Louise} and Mads Thomassen and Mirolyuba Ilieva and Morten Meyer and {Fex Svenningsen}, {\AA}sa and Sheldrick-Michel, {Tanja Maria}",

year = "2021",

month = mar,

doi = "10.1016/j.scr.2021.102185",

language = "English",

volume = "51",

journal = "Stem Cell Research",

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T1 - Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

AU - Kamand, Morad

AU - Forsberg, Sheena Louise

AU - Thomassen, Mads

AU - Ilieva, Mirolyuba

AU - Meyer, Morten

AU - Fex Svenningsen, Åsa

AU - Sheldrick-Michel, Tanja Maria

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AB - Autism is a complex neuropsychiatric disorder defined by significant challenges in communication skills and social behavior as well as repetitive conduct and interests. Recent advances in stem cell technologies allow in vitro modeling of the underlying molecular disease mechanisms. Using integration-free episomal plasmids, we have generated a novel iPS cell line (SDUKIi006-A) from a patient diagnosed with atypical autism (“FYNEN cohort” of Southern Denmark). Characterization of the established cell line validated its expression of pluripotency markers, differentiation into the three germ layers, and the absence of chromosomal abnormalities.

U2 - 10.1016/j.scr.2021.102185

DO - 10.1016/j.scr.2021.102185

M3 - Journal article

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SN - 1873-5061

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M1 - 102185

ER -

Establishment of an induced pluripotent stem (iPS) cell line (SDUKIi006-A) from a 21-year old male patient diagnosed with atypical autism disorder

Abstract

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Related research output

Studying autism spectrum disorders (ASD) using a three-dimensional brain organoid model derived from patient-specific induced pluripotent stem cells (iPSCs): Autism from skin to brain

Cite this