Environmental risk factors in neuromyelitis optica spectrum disorder: a case–control study

Sharareh Eskandarieh, Saharnaz Nedjat, Ibrahim Abdollahpour, Amir Reza Azimi, Abdorreza Naser Moghadasi, Nasrin Asgari, Mohammad Ali Sahraian*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Neuromyelitis optica spectrum disorder (NMOSD) has unknown risk factors. The aim of this study was to identify the environmental risk factors for NMOSD. A case–control study was conducted in Tehran from 2015 to 2016 among 100 patients with NMOSD. Sex-matched healthy controls (n = 400) were selected through random digit dialing (RDD). Logistic regression was used to estimate unadjusted and adjusted ORs (odds ratio) at 95% confidence intervals (CI) via SPSS. Compared with the control population, in NMOSD patients, the adjusted OR for low dairy consumption per week was (OR = 18.09; 95% CI 6.91, 47.37), following low sea food intake (OR = 13.91; 95% CI 6.13, 31.57) and low fruit and vegetable consumption (OR = 6.23; 95% CI 3.07, 12.62). The lower heavy physical activity (OR: 16.11, 95% CI 7.03, 36.91) among patients had risen the risk of NMOSD. A past history of head trauma was considered a risk for NMOSD (OR: 8.39, 95% CI 4.97, 14.16). The association between NMOSD and intentional abortion only among females (OR: 7.42, 95% CI 2.81, 19.55) was detected. This study indicates significant associations between dietary habits, life style, history of head trauma and intentional abortion in female and the later diagnosis of NMOSD.

Original languageEnglish
JournalActa Neurologica Belgica
Issue number2
Pages (from-to)277-287
Publication statusPublished - Jun 2018


  • Case–control
  • Neuromyelitis optica spectrum disorder
  • Risk factor

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