Elements in normal and cirrhotic human liver. Potassium, iron, copper, zinc and bromine measured by X-ray fluorescence spectrometry

J. Laursen, N. Milman, Peter Mygind Leth, S. Asnæs

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Various elements (K, Fe, Cu, Zn, Br) were measured by X-ray flourescence spectrometry in cellular and connective tissue fractions of normal and cirrhotic liver samples obtained at autopsy. Normal livers: 32 subjects (16 males, 16 females) median age 69 years. Cirrhotic livers: 14 subjects (13 males, 1 female) with alcoholic cirrhosis, median age 55 years. Cellular and connective tissue fractions were separated by blending and sieving of the liver samples. Normal livers:K, Cu and Zn content was higher, and Br content lower in the cellular than in the connective tissue fractions. Median values in cellular/connective tissue fractions in mmol/kg/dry weight were: K, 121.04/48.67, p<0.0001; Fe, 16.12/13.95, NS; Cu, 0.326/0.223, p<0.001; Zn, 3.20/2.78, p<0.02; Br, 0.0838/0.1827, p<0.0001. Cirrhotic livers: K content was higher and Br content lower in cellular than in connective tissue fractions, while Fe, Cu and Zn displayed no difference. K, 122.42/22.58, p<0.0001; Fe, 13.00/16.58, NS; Cu, 0.444/0.595, NS; Zn, 2.19/2.07, NS; Br, 0.1602/0.2340, p<0.001. In cellular fractions of cirrhotic livers, K and Fe content was within the normal range, Zn content lower (p<0.03), and Cu and Br content higher (p<0.01, p<0.04) than normal. In connective tissue fractions of cirrhotic livers, Fe content was within normal range, K and Zn content lower (p<0.0001, p<0.03), and Cu and Br content higher (p<0.01, p<0.001) than normal. From a practical point of view, when assessing element content in cirrhotic livers, it does not seem necessary to correct for the connective tissue content.
Original languageEnglish
JournalTrace Elements in Medicine
Volume7
Issue number3
Pages (from-to)118-123
Publication statusPublished - 1990

Keywords

  • cirrhosis
  • trace elements

Fingerprint

Dive into the research topics of 'Elements in normal and cirrhotic human liver. Potassium, iron, copper, zinc and bromine measured by X-ray fluorescence spectrometry'. Together they form a unique fingerprint.

Cite this