TY - JOUR
T1 - Effects of population-based screening for atrial fibrillation on quality of life
AU - Kongebro, Emilie Katrine
AU - Kronborg, Christian
AU - Xing, Lucas Yixi
AU - Haugan, Ketil Jørgen
AU - Graff, Claus
AU - Højberg, Søren
AU - Olesen, Morten S
AU - Krieger, Derk
AU - Brandes, Axel
AU - Køber, Lars
AU - Svendsen, Jesper Hastrup
AU - Diederichsen, Søren Zöga
PY - 2025/1/12
Y1 - 2025/1/12
N2 - BACKGROUND: Screening for atrial fibrillation is rising and may worsen or improve quality of life.METHODS: We assessed quality of life (EQ-5D-5L) data in 6,004 participants with stroke risk factors randomised to usual care (n=4,503) or implantable loop recorder with anticoagulation upon detection of atrial fibrillation (n=1,501). Five domains (mobility, selfcare, usual activities, pain/discomfort, anxiety/depression) each scored from one to five were calculated into individual index scores (worst=-0.76, best=1.00). Changes in the index score and the visual analogue scale score (EQ VAS (0=worst, 100=best)) from baseline to year three were the primary outcomes, which were analysed using linear mixed models. Major problem was defined as a domain score ≥3 and analysed with logistic regression in year three.RESULTS: Of 6,004 participants, 5,733 (95 %) were alive after three years, and 5,162 (86 %) had complete EQ-5D-5L data. The baseline index score of 5,733 participants was 0.88 ±0.16, which decreased by -0.05 (-0.05; -0.04) in the control vs -0.04 (-0.05; -0.03) in the screening group after three years, and a baseline EQ VAS score of 78.4±16.2, which decreased by -6.06 (-6.54; -5.57) in control vs -5.18 (-5.95; -4.40) in the screening group after three years, with no significant difference between the groups (p=0.063 and p=0.056, respectively). The most frequent problem was major pain/discomfort (1,202 of 5,162 (23.3 %)), and any major problem occurred equally in the groups after three years (OR 0.91 (0.79;1.05)).CONCLUSION: A population-based, long-term, and continuous screening for atrial fibrillation in high-risk individuals did not translate into increased quality of life.
AB - BACKGROUND: Screening for atrial fibrillation is rising and may worsen or improve quality of life.METHODS: We assessed quality of life (EQ-5D-5L) data in 6,004 participants with stroke risk factors randomised to usual care (n=4,503) or implantable loop recorder with anticoagulation upon detection of atrial fibrillation (n=1,501). Five domains (mobility, selfcare, usual activities, pain/discomfort, anxiety/depression) each scored from one to five were calculated into individual index scores (worst=-0.76, best=1.00). Changes in the index score and the visual analogue scale score (EQ VAS (0=worst, 100=best)) from baseline to year three were the primary outcomes, which were analysed using linear mixed models. Major problem was defined as a domain score ≥3 and analysed with logistic regression in year three.RESULTS: Of 6,004 participants, 5,733 (95 %) were alive after three years, and 5,162 (86 %) had complete EQ-5D-5L data. The baseline index score of 5,733 participants was 0.88 ±0.16, which decreased by -0.05 (-0.05; -0.04) in the control vs -0.04 (-0.05; -0.03) in the screening group after three years, and a baseline EQ VAS score of 78.4±16.2, which decreased by -6.06 (-6.54; -5.57) in control vs -5.18 (-5.95; -4.40) in the screening group after three years, with no significant difference between the groups (p=0.063 and p=0.056, respectively). The most frequent problem was major pain/discomfort (1,202 of 5,162 (23.3 %)), and any major problem occurred equally in the groups after three years (OR 0.91 (0.79;1.05)).CONCLUSION: A population-based, long-term, and continuous screening for atrial fibrillation in high-risk individuals did not translate into increased quality of life.
U2 - 10.1016/j.ejim.2024.12.035
DO - 10.1016/j.ejim.2024.12.035
M3 - Journal article
C2 - 39800594
SN - 0953-6205
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
ER -