Effects of football fitness training on lymphedema and upper-extremity function in women after treatment for breast cancer: a randomized trial

Kira Bloomquist*, Peter Krustrup, Bjørn Fristrup, Victor Sørensen, Jørn Wulff Helge, Eva Wulff Helge, Eva Soelberg Vadstrup, Mikael Rørth, Sandra C. Hayes, Jacob Uth

*Corresponding author for this work

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Abstract

Background: Breast cancer survivors are encouraged to be physically active. A recent review suggests that football training is an effective exercise modality for women across the lifespan, positively influencing health variables such as strength, fitness and social well-being. However, football is a contact sport, potentially posing an increased risk of trauma-related injury. Against this backdrop, breast cancer survivors are advised to avoid trauma or injury to the affected or at-risk arm in order to protect against lymphedema onset or exacerbation. The aim of this study was therefore to evaluate the feasibility and safety of Football Fitness training in relation to lymphedema and upper-extremity function after treatment for breast cancer. Material and methods: Sixty-eight women aged 18–75 years, who had received surgery for stage I-III breast cancer and completed (neo) adjuvant chemotherapy and/or radiotherapy within five years, were randomized (2:1) to a Football Fitness group (FFG, n = 46) or a control group (CON, n = 22) for twelve months. Secondary analyses using linear mixed models were performed to assess changes in upper-body morbidity, specifically arm lymphedema (inter-arm volume % difference, dual energy X-ray absorptiometry; extracellular fluid (L-Dex), bioimpedance spectroscopy), self-reported breast and arm symptoms (EORTC breast cancer-specific questionnaire (BR23) and upper-extremity function (DASH questionnaire) at baseline, six- and twelve-month follow-up. Results: We observed similar point prevalent cases of lymphedema between groups at all time points, irrespective of measurement method. At the six-month post-baseline assessment, reductions in L-Dex (extracellular fluid) were found in FFG versus CON. These significant findings were not maintained at the twelve-month assessment. No difference between groups was observed for inter-limb volume difference %, nor any of the remaining outcomes. Conclusion: While superiority of Football Fitness was not observed, the results support that participation in Football Fitness training is feasible and suggests no negative effects on breast cancer-specific upper-body morbidity, including lymphedema. Trial registration: The trial was registered at ClinicalTrials.gov. NCT03284567.

Original languageEnglish
JournalActa Oncologica
Volume60
Issue number3
Pages (from-to)392-400
ISSN0284-186X
DOIs
Publication statusPublished - 2021

Keywords

  • Breast cancer
  • exercise
  • lymphedema
  • soccer
  • upper-body morbidity

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