Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males

Cyrus Ayubcha, Mahdi Zirakchian Zadeh, Chamith S Rajapakse, Jan Hartvigsen, Mette Jensen Stochkendahl, William Raynor, Oswaldo Acosta-Montenegro, Thomas Werner, Hongming Zhuang, Poul F Høilund-Carlsen, Abass Alavi

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Objective: This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using uorine-18 uorodeoxyglucose positron emission tomography ( 18F-FDG PET) imaging. Subjects and Methods: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects' 18F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region. Results: SUVmean increased signicantly with weight in both the thoracic spine (Slope=0.0066, P= 0.001) and lumbar spine (Slope=0.0087, P<0.0001), but not the cervical spine. There were no signicant correlations between age and SUVmean in all three regions. The cervical spine (average SUVmean=1.84±0.31) illustrated elevated activity when compared to the thoracic (average SUVmean=1.46±0.27, P<0.0001) and lumbar (average SUVmean=1.41±0.28, P<0.0001) spines. Conclusion: This study illustrated the ability of 18F-FDG PET to assess metabolic processes in the spine. The data provided evidence of weight dependent metabolic activity, likely related to inammation. This study offers a methodological precedent that can be applied to studies in populations with back pain.

Original languageEnglish
JournalHellenic Journal of Nuclear Medicine
Volume21
Issue number1
Pages (from-to)2-6
ISSN1790-5427
Publication statusPublished - 20. Mar 2018

Fingerprint

Fluorodeoxyglucose F18
Weights and Measures
Population

Keywords

  • Adult
  • Aged
  • Aging/metabolism
  • Axis, Cervical Vertebra/diagnostic imaging
  • Body Weight
  • Fluorodeoxyglucose F18
  • Healthy Volunteers
  • Humans
  • Lumbar Vertebrae/diagnostic imaging
  • Male
  • Middle Aged
  • Pain/diagnostic imaging
  • Positron-Emission Tomography
  • Spine/diagnostic imaging
  • Thoracic Vertebrae/diagnostic imaging
  • Young Adult

Cite this

Ayubcha, Cyrus ; Zadeh, Mahdi Zirakchian ; Rajapakse, Chamith S ; Hartvigsen, Jan ; Stochkendahl, Mette Jensen ; Raynor, William ; Acosta-Montenegro, Oswaldo ; Werner, Thomas ; Zhuang, Hongming ; Høilund-Carlsen, Poul F ; Alavi, Abass. / Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males. In: Hellenic Journal of Nuclear Medicine. 2018 ; Vol. 21, No. 1. pp. 2-6.
@article{d2f2a913302042a7841d6728383e6e5b,
title = "Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males",
abstract = "Objective: This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using uorine-18 uorodeoxyglucose positron emission tomography ( 18F-FDG PET) imaging. Subjects and Methods: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects' 18F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region. Results: SUVmean increased signicantly with weight in both the thoracic spine (Slope=0.0066, P= 0.001) and lumbar spine (Slope=0.0087, P<0.0001), but not the cervical spine. There were no signicant correlations between age and SUVmean in all three regions. The cervical spine (average SUVmean=1.84±0.31) illustrated elevated activity when compared to the thoracic (average SUVmean=1.46±0.27, P<0.0001) and lumbar (average SUVmean=1.41±0.28, P<0.0001) spines. Conclusion: This study illustrated the ability of 18F-FDG PET to assess metabolic processes in the spine. The data provided evidence of weight dependent metabolic activity, likely related to inammation. This study offers a methodological precedent that can be applied to studies in populations with back pain.",
keywords = "Adult, Aged, Aging/metabolism, Axis, Cervical Vertebra/diagnostic imaging, Body Weight, Fluorodeoxyglucose F18, Healthy Volunteers, Humans, Lumbar Vertebrae/diagnostic imaging, Male, Middle Aged, Pain/diagnostic imaging, Positron-Emission Tomography, Spine/diagnostic imaging, Thoracic Vertebrae/diagnostic imaging, Young Adult",
author = "Cyrus Ayubcha and Zadeh, {Mahdi Zirakchian} and Rajapakse, {Chamith S} and Jan Hartvigsen and Stochkendahl, {Mette Jensen} and William Raynor and Oswaldo Acosta-Montenegro and Thomas Werner and Hongming Zhuang and H{\o}ilund-Carlsen, {Poul F} and Abass Alavi",
year = "2018",
month = "3",
day = "20",
language = "English",
volume = "21",
pages = "2--6",
journal = "Hellenic Journal of Nuclear Medicine",
issn = "1108-1430",
publisher = "Hellenic Society of Nuclear Medicine",
number = "1",

}

Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males. / Ayubcha, Cyrus; Zadeh, Mahdi Zirakchian; Rajapakse, Chamith S; Hartvigsen, Jan; Stochkendahl, Mette Jensen; Raynor, William; Acosta-Montenegro, Oswaldo; Werner, Thomas; Zhuang, Hongming; Høilund-Carlsen, Poul F; Alavi, Abass.

In: Hellenic Journal of Nuclear Medicine, Vol. 21, No. 1, 20.03.2018, p. 2-6.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Effects of age and weight on the metabolic activities of the cervical, thoracic and lumbar spines as measured by fluorine-18 fluorodeoxyglucose-positron emission tomography in healthy males

AU - Ayubcha, Cyrus

AU - Zadeh, Mahdi Zirakchian

AU - Rajapakse, Chamith S

AU - Hartvigsen, Jan

AU - Stochkendahl, Mette Jensen

AU - Raynor, William

AU - Acosta-Montenegro, Oswaldo

AU - Werner, Thomas

AU - Zhuang, Hongming

AU - Høilund-Carlsen, Poul F

AU - Alavi, Abass

PY - 2018/3/20

Y1 - 2018/3/20

N2 - Objective: This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using uorine-18 uorodeoxyglucose positron emission tomography ( 18F-FDG PET) imaging. Subjects and Methods: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects' 18F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region. Results: SUVmean increased signicantly with weight in both the thoracic spine (Slope=0.0066, P= 0.001) and lumbar spine (Slope=0.0087, P<0.0001), but not the cervical spine. There were no signicant correlations between age and SUVmean in all three regions. The cervical spine (average SUVmean=1.84±0.31) illustrated elevated activity when compared to the thoracic (average SUVmean=1.46±0.27, P<0.0001) and lumbar (average SUVmean=1.41±0.28, P<0.0001) spines. Conclusion: This study illustrated the ability of 18F-FDG PET to assess metabolic processes in the spine. The data provided evidence of weight dependent metabolic activity, likely related to inammation. This study offers a methodological precedent that can be applied to studies in populations with back pain.

AB - Objective: This study aimed to explore the age and weight-related metabolic trends in the spines of healthy male subjects using uorine-18 uorodeoxyglucose positron emission tomography ( 18F-FDG PET) imaging. Subjects and Methods: Forty three healthy male subjects (age 23-75 years, weight 50-145kg) were selected from the CAMONA study. A global assessment methodology was applied to the subjects' 18F-FDG 180 minute scans, where each region of the spine (cervical, thoracic and lumbar) was individually encapsulated in a single region of interest, and standardized uptake value (SUVmean) was calculated per respective region. Results: SUVmean increased signicantly with weight in both the thoracic spine (Slope=0.0066, P= 0.001) and lumbar spine (Slope=0.0087, P<0.0001), but not the cervical spine. There were no signicant correlations between age and SUVmean in all three regions. The cervical spine (average SUVmean=1.84±0.31) illustrated elevated activity when compared to the thoracic (average SUVmean=1.46±0.27, P<0.0001) and lumbar (average SUVmean=1.41±0.28, P<0.0001) spines. Conclusion: This study illustrated the ability of 18F-FDG PET to assess metabolic processes in the spine. The data provided evidence of weight dependent metabolic activity, likely related to inammation. This study offers a methodological precedent that can be applied to studies in populations with back pain.

KW - Adult

KW - Aged

KW - Aging/metabolism

KW - Axis, Cervical Vertebra/diagnostic imaging

KW - Body Weight

KW - Fluorodeoxyglucose F18

KW - Healthy Volunteers

KW - Humans

KW - Lumbar Vertebrae/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Pain/diagnostic imaging

KW - Positron-Emission Tomography

KW - Spine/diagnostic imaging

KW - Thoracic Vertebrae/diagnostic imaging

KW - Young Adult

M3 - Journal article

C2 - 29550840

VL - 21

SP - 2

EP - 6

JO - Hellenic Journal of Nuclear Medicine

JF - Hellenic Journal of Nuclear Medicine

SN - 1108-1430

IS - 1

ER -