Effectiveness of a stepped care intervention for anxiety and depression in people with diabetes, asthma or COPD in primary care: A randomized controlled trial

C H Stoop, Giesje Nefs, A M Pommer, V J M Pop, F Pouwer

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BACKGROUND: Depression and anxiety are common in people with a chronic somatic disease. Although guidelines recommend stepped care, the effectiveness of this approach has not been evaluated in people with diabetes, asthma, or COPD in primary care.

METHODS: 3559 People were sent screening questionnaires (41% response). Of 286 persons with anxiety and/or depression (Generalized Anxiety Disorder questionnaire, GAD-7, cut-off ≥ 8 and/or Patient Health Questionnaire, PHQ-9, cut-off ≥ 7), 46 were randomized into the intervention (stepped care and monitoring of symptoms; n = 23) or control (usual care) group (n = 23). Main outcomes were symptoms of anxiety and depression after the 12-months intervention and six months post intervention. Analysis of covariance was first adjusted for condition and baseline GAD-7/PHQ-9 scores and additionally for age, sex and education.

RESULTS: The intervention group had a significantly lower level of anxiety symptoms at the end of the program (GAD-7 6 ± 6 vs. 9 ± 6; Cohen's d = 0.61). This effect was still present six months post intervention. The effect on depression was statistically significant in the first model (PHQ-9 6 ± 4 vs. 9 ± 6; p = 0.035), but not in the fully adjusted model (p = 0.099), despite a large effect size (d = 0.63). At six months post intervention there was no statistically significant difference in symptoms of depression between the two groups although the difference in symptoms was still clinically significant (Cohen's d = 0.61).

LIMITATIONS: Many people were screened, but relatively few participated in the randomized controlled trial.

CONCLUSIONS: Stepped care with monitoring resulted in a lower level of symptoms of anxiety and depression in people with a chronic condition.

Original languageEnglish
JournalJournal of Affective Disorders
Volume184
Pages (from-to)269-76
ISSN0165-0327
DOIs
Publication statusPublished - 15. Sep 2015
Externally publishedYes

Keywords

  • Anxiety
  • Asthma
  • Cognitive Therapy
  • Depression
  • Depressive Disorder
  • Diabetes Complications
  • Female
  • Humans
  • Male
  • Middle Aged
  • Primary Health Care
  • Pulmonary Disease, Chronic Obstructive
  • Suicidal Ideation
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

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