Effect of Tofacitinib in a Patient with Inflammatory Bowel Disease-Related Arthritis

Niels Lomborg*, Michael Dam Jensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Extraintestinal manifestations are common in patients with chronic inflammatory bowel disease (IBD). Peripheral arthritis occurs in ∼10% of patients with IBD. Treatment of both arthritis and the IBD disease is challenging, and involvement of both the rheumatologist and the gastroenterologist is essential. We present a case with concomitant polyarthritis and ulcerative colitis successfully treated with tofacitinib. A 32-year-old woman with ulcerative colitis currently treated with azathioprine and adalimumab was referred to our rheumatology clinic due to pain and swelling in her knees and finger joints. The patient was diagnosed with IBD-related arthritis. Intra-articular injection with steroid was initially effective, but the arthritis was persistent. Treatment attempts with salazopyrine and golimumab were discontinued due to drug-induced pancreatitis and urticaria, respectively. Subsequently treatment with tofacitinib 10 mg twice daily was effective within weeks, and apart from a mild folliculitis, there were no side effects. With this case report, we would like to draw attention to the fact that treatment with tofacitinib may constitute a good treatment option in refractory cases of IBD-related arthritis.

Original languageEnglish
JournalModern Rheumatology Case Reports
Volume6
Issue number2
Pages (from-to)171-172
ISSN2472-5625
DOIs
Publication statusPublished - 24. Jun 2022

Bibliographical note

© Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords

  • Adult
  • Arthritis/diagnosis
  • Colitis, Ulcerative/complications
  • Female
  • Humans
  • Inflammatory Bowel Diseases/complications
  • Piperidines/therapeutic use
  • Pyrimidines

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