Effect of preservation of the right gastro-epiploic artery on delayed gastric emptying after cytoreductive surgery and HIPEC: A randomized clinical trial

D. J. Evers*, R. M. Smeenk, P. D. Bottenberg, E. D. van Werkhoven, H. Boot, V. J. Verwaal

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: Delayed gastric emptying (DGE) is a main complication with unknown origin after a cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS-HIPEC). The aim of this study was to investigate if preservation of the right gastro-epiploic artery (GEA) during standard omentectomy would have a positive effect on gastric emptying after CRS-HIPEC.

Methods: Forty-two patients subjected to a CRS-HIPEC were randomized into two groups perioperatively before performing an omentectomy: in Group I (N = 21) omentectomy was performed with preservation of the GEA; in Group It (N = 21) omentectomy was performed with resection of the GEA. The primary endpoint was the number of days to full oral intake of solid food. Secondary endpoints were number of days to intended occlusion of gastrostomy catheter and total hospital admission time.

Results: No significant differences were discovered between both groups in any of the study endpoints after CRS-HIPEC. No significant differences were observed in patient or operation characteristics between the randomized groups.

Conclusions: No association was demonstrated between preservation of the gastro-epiploic artery during omentectomy and gastric emptying after CRS-HIPEC. The extensive intestinal manipulation or the heated intra-peritoneal chemotherapy during surgery are more plausible causes of this phenomenon. This clinical trial was registered in the Netherlands at the Central Committee on Research involving Human Subjects (CCMO) under registration number P06.0301L. (C) 2010 Elsevier Ltd. All rights reserved.

Original languageEnglish
JournalEuropean Journal of Surgical Oncology
Volume37
Issue number2
Pages (from-to)162-167
Number of pages6
ISSN0748-7983
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes
Event7th International Workshop on Peritoneal Surface Malignancy - Uppsala, Sweden
Duration: 8. Sep 201010. Sep 2010

Conference

Conference7th International Workshop on Peritoneal Surface Malignancy
CountrySweden
CityUppsala
Period08/09/201010/09/2010

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