Effect of exercise on platelet activation during aspirin or clopidogrel intake in healthy men

Esben Hjorth Madsen, Morten Krogh Christiansen, Erik Berg Schmidt, Tina Svenstrup Poulsen, Søren Risom Kristensen

Research output: Contribution to journalJournal article

Abstract

Sudden strenuous exercise increases the risk of ischemic cardiac events in patients with coronary artery disease. The exact mechanism behind this observation is unknown, but platelet activation induced by exercise may be of importance. We hypothesized that brief strenuous exercise would activate platelets in healthy men, assessed by the Platelet Function Analyzer 100 and light transmittance aggregometry. Nearly all participants exhibited increased platelet reactivity after exercise measured by the Platelet Function Analyzer 100, whereas only minor changes were detected by light transmittance aggregometry. A significant increase in plasma von Willebrand Factor was also found in response to exercise. In conclusion, platelet activation occurs during exercise in healthy individuals. This activation is not prevented by use of aspirin or clopidogrel, and may partly be explained by an increase in plasma von Willebrand Factor.
Original languageEnglish
JournalPlatelets
Volume20
Issue number3
Pages (from-to)177-82
Number of pages5
ISSN0953-7104
DOIs
Publication statusPublished - 1. May 2009

Keywords

  • Adolescent
  • Adult
  • Aspirin
  • Exercise
  • Humans
  • Male
  • Middle Aged
  • Platelet Activation
  • Platelet Aggregation Inhibitors
  • Ticlopidine
  • Young Adult
  • von Willebrand Factor

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    Hjorth Madsen, E., Christiansen, M. K., Schmidt, E. B., Poulsen, T. S., & Kristensen, S. R. (2009). Effect of exercise on platelet activation during aspirin or clopidogrel intake in healthy men. Platelets, 20(3), 177-82. https://doi.org/10.1080/09537100902795484