Effect of empagliflozin on myocardial structure and function in patients with type 2 diabetes at high cardiovascular risk: the SIMPLE randomized clinical trial

Mads Ersbøll*, Mikkel Jürgens, Philip Hasbak, Andreas Kjær, Emil Wolsk, Bo Zerahn, Niels H. Brandt-Jacobsen, Peter Gæde, Peter Rossing, Jens Faber, Silvio E. Inzucchi, Finn Gustafsson, Morten Schou, Caroline Kistorp

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

To investigate the effects of 13 weeks treatment with empagliflozin in patients with high-risk type-2 diabetes mellitus on echocardiographic measures of left ventricular (LV) structure and function compared to placebo. A total of 91 patients were randomized to treatment with empagliflozin (25 mg/day, n = 45) or matching placebo (n = 45) for 13 weeks. Left ventricular (LV) mass, volumes and geometry as well as measures of LV systolic and diastolic function were measured using echocardiography at baseline and follow up. Mean LV mass index (LVMi) was reduced by − 11.5 g/m2 (95% CI − 56.4; 33.4, p = 0.03) with empagliflozin compared to − 1.4 g/m2 (95% CI − 36.5; 33.8, p = 0.63) for placebo. The proportion of patients with LV hypertrophy was reduced by 16.3% (p = 0.04) in the empagliflozin group compared to 1.1% in the placebo group (p = 1.00). The proportion of patients with left atrial volume index > 34 mL/m2 was reduced by 20.0% (p = 0.02) with empagliflozin compared to 9.5% for placebo (p = 0.45) and the E/e′ ratio decreased (∆-0.8 (1.9) vs. ∆0.5 (2.0), p < 0.01). 13 weeks empagliflozin treatment in patients with type-2 diabetes at high CV risk significantly reduced LV mass, improved LV geometry and improved diastolic function compared to placebo.

Original languageEnglish
JournalInternational Journal of Cardiovascular Imaging
ISSN1569-5794
DOIs
Publication statusE-pub ahead of print - 20. Oct 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature B.V.

Keywords

  • Echocardiography
  • Left ventricular hypertrophy
  • SGLT2i
  • Type-2 diabetes

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