Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula

K Bech, C P Hovendal, D Andersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade or adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol, which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the beta 1-adrenoceptor blocker practolol, the alpha-adrenoceptor blocker phentolamine, or the alpha + beta-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. beta-Adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.

Original languageEnglish
Book seriesScandinavian Journal of Gastroenterology. Supplement
Volume17
Issue number1
Pages (from-to)103-7
Number of pages5
ISSN0036-5521
Publication statusPublished - Jan 1982

Fingerprint

Gastric Fistula
Pentagastrin
Adrenergic Receptors
Dogs
Flupenthixol
Practolol
Labetalol
Domperidone
Phentolamine
Receptors, Adrenergic, beta
Gastric Acid

Keywords

  • Adrenergic alpha-Antagonists
  • Adrenergic beta-Antagonists
  • Animals
  • Dogs
  • Dopamine
  • Female
  • Gastrointestinal Motility
  • Male
  • Pentagastrin
  • Pyloric Antrum
  • Receptors, Dopamine
  • Stomach

Cite this

@article{88abb7de1d274b88a76f6a9a54cd4005,
title = "Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula",
abstract = "The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade or adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol, which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the beta 1-adrenoceptor blocker practolol, the alpha-adrenoceptor blocker phentolamine, or the alpha + beta-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. beta-Adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.",
keywords = "Adrenergic alpha-Antagonists, Adrenergic beta-Antagonists, Animals, Dogs, Dopamine, Female, Gastrointestinal Motility, Male, Pentagastrin, Pyloric Antrum, Receptors, Dopamine, Stomach",
author = "K Bech and Hovendal, {C P} and D Andersen",
year = "1982",
month = "1",
language = "English",
volume = "17",
pages = "103--7",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "1",

}

Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula. / Bech, K; Hovendal, C P; Andersen, D.

In: Scandinavian Journal of Gastroenterology. Supplement, Vol. 17, No. 1, 01.1982, p. 103-7.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Effect of dopamine on pentagastrin-stimulated gastric antral motility in dogs with gastric fistula

AU - Bech, K

AU - Hovendal, C P

AU - Andersen, D

PY - 1982/1

Y1 - 1982/1

N2 - The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade or adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol, which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the beta 1-adrenoceptor blocker practolol, the alpha-adrenoceptor blocker phentolamine, or the alpha + beta-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. beta-Adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.

AB - The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade or adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol, which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the beta 1-adrenoceptor blocker practolol, the alpha-adrenoceptor blocker phentolamine, or the alpha + beta-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. beta-Adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.

KW - Adrenergic alpha-Antagonists

KW - Adrenergic beta-Antagonists

KW - Animals

KW - Dogs

KW - Dopamine

KW - Female

KW - Gastrointestinal Motility

KW - Male

KW - Pentagastrin

KW - Pyloric Antrum

KW - Receptors, Dopamine

KW - Stomach

M3 - Journal article

VL - 17

SP - 103

EP - 107

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 1

ER -