Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues

Secondary Analyses from a Randomized Clinical Trial

Regitse Højgaard Christensen*, Anne Sophie Wedell-Neergaard, Louise Lang Lehrskov, Grit Elster Legaard, Emma Dorph, Monica Korsager Larsen, Natja Launbo, Sabrina Ravn Fagerlind, Sidsel Kofoed Seide, Stine Nymand, Maria Ball, Nicole Buchner Vinum, Camilla Nørfelt Dahl, Marie Henneberg, Mathias Ried-Larsen, Mikael Ploug Boesen, Robin Christensen, Kristian Karstoft, Rikke Krogh-Madsen, Jaya Birgitte Rosenmeier & 2 others Bente Klarlund Pedersen, Helga Ellingsgaard

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Importance: Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots. Objective: To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass. Design, Setting, and Participants: Secondary analysis of a randomized, assessor-blinded clinical trial initiated on August 2016 and completed April 2018. This single-center, community-based study included 50 physically inactive participants with abdominal obesity. Interventions: Participants were randomized to a supervised high-intensity interval endurance training (3 times a week for 45 minutes), resistance training (3 times a week for 45 minutes), or no exercise (control group). Main Outcomes and Measures: Change in epicardial and pericardial adipose tissue mass assessed by magnetic resonance imaging, based on a prespecified secondary analysis plan including 3 of 5 parallel groups. Results: Of 50 participants (mean [SD] age, 41 [14] years, 10 men [26%]; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32 [5]), 39 [78%] completed the study. Endurance training and resistance training reduced epicardial adipose tissue mass by 32% (95% CI, 10%-53%) and 24% (95% CI, 1%-46%), respectively, compared with the no exercise control group (56% [95% CI, 24%-88%]; P =.001 and 48% [95% CI, 15%-81%]; P <.001, respectively). While there was a nonsignificant reduction in pericardial adipose tissue mass after endurance training (11% [95% CI, -5% to 27%]; P =.17), resistance training significantly reduced pericardial adipose tissue mass by 31% (95% CI, 16%-47%; P <.001) when compared with the no exercise control group. Compared with the no exercise control group, there was an increase in left ventricular mass by endurance (20 g [95% CI, 11%-30%]; P <.001) and resistance training (18 g [95% CI, 8%-28%]; P <.001). Other cardiometabolic outcomes remained unchanged after the 12-week trial period. Conclusions and Relevance: In individuals with abdominal obesity, both endurance and resistance training reduced epicardial adipose tissue mass, while only resistance training reduced pericardial adipose tissue mass. These data highlight the potential preventive importance of different exercise modalities as means to reduce cardiac fat in individuals with abdominal obesity. Trial Registration: ClinicalTrials.gov identifier: NCT02901496.

Original languageEnglish
JournalJAMA Cardiology
Volume4
Issue number8
Pages (from-to)778-787
ISSN2380-6583
DOIs
Publication statusPublished - 1. Aug 2019

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Resistance Training
Adipose Tissue
Randomized Controlled Trials
Exercise
Abdominal Obesity
Control Groups
Fats
Body Mass Index
Outcome Assessment (Health Care)
Clinical Trials
Weights and Measures

Cite this

Christensen, R. H., Wedell-Neergaard, A. S., Lehrskov, L. L., Legaard, G. E., Dorph, E., Larsen, M. K., ... Ellingsgaard, H. (2019). Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses from a Randomized Clinical Trial. JAMA Cardiology, 4(8), 778-787. https://doi.org/10.1001/jamacardio.2019.2074
Christensen, Regitse Højgaard ; Wedell-Neergaard, Anne Sophie ; Lehrskov, Louise Lang ; Legaard, Grit Elster ; Dorph, Emma ; Larsen, Monica Korsager ; Launbo, Natja ; Fagerlind, Sabrina Ravn ; Seide, Sidsel Kofoed ; Nymand, Stine ; Ball, Maria ; Vinum, Nicole Buchner ; Dahl, Camilla Nørfelt ; Henneberg, Marie ; Ried-Larsen, Mathias ; Boesen, Mikael Ploug ; Christensen, Robin ; Karstoft, Kristian ; Krogh-Madsen, Rikke ; Rosenmeier, Jaya Birgitte ; Pedersen, Bente Klarlund ; Ellingsgaard, Helga. / Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues : Secondary Analyses from a Randomized Clinical Trial. In: JAMA Cardiology. 2019 ; Vol. 4, No. 8. pp. 778-787.
@article{b0afffe800aa41fc87865d82062261ef,
title = "Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses from a Randomized Clinical Trial",
abstract = "Importance: Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots. Objective: To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass. Design, Setting, and Participants: Secondary analysis of a randomized, assessor-blinded clinical trial initiated on August 2016 and completed April 2018. This single-center, community-based study included 50 physically inactive participants with abdominal obesity. Interventions: Participants were randomized to a supervised high-intensity interval endurance training (3 times a week for 45 minutes), resistance training (3 times a week for 45 minutes), or no exercise (control group). Main Outcomes and Measures: Change in epicardial and pericardial adipose tissue mass assessed by magnetic resonance imaging, based on a prespecified secondary analysis plan including 3 of 5 parallel groups. Results: Of 50 participants (mean [SD] age, 41 [14] years, 10 men [26{\%}]; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32 [5]), 39 [78{\%}] completed the study. Endurance training and resistance training reduced epicardial adipose tissue mass by 32{\%} (95{\%} CI, 10{\%}-53{\%}) and 24{\%} (95{\%} CI, 1{\%}-46{\%}), respectively, compared with the no exercise control group (56{\%} [95{\%} CI, 24{\%}-88{\%}]; P =.001 and 48{\%} [95{\%} CI, 15{\%}-81{\%}]; P <.001, respectively). While there was a nonsignificant reduction in pericardial adipose tissue mass after endurance training (11{\%} [95{\%} CI, -5{\%} to 27{\%}]; P =.17), resistance training significantly reduced pericardial adipose tissue mass by 31{\%} (95{\%} CI, 16{\%}-47{\%}; P <.001) when compared with the no exercise control group. Compared with the no exercise control group, there was an increase in left ventricular mass by endurance (20 g [95{\%} CI, 11{\%}-30{\%}]; P <.001) and resistance training (18 g [95{\%} CI, 8{\%}-28{\%}]; P <.001). Other cardiometabolic outcomes remained unchanged after the 12-week trial period. Conclusions and Relevance: In individuals with abdominal obesity, both endurance and resistance training reduced epicardial adipose tissue mass, while only resistance training reduced pericardial adipose tissue mass. These data highlight the potential preventive importance of different exercise modalities as means to reduce cardiac fat in individuals with abdominal obesity. Trial Registration: ClinicalTrials.gov identifier: NCT02901496.",
author = "Christensen, {Regitse H{\o}jgaard} and Wedell-Neergaard, {Anne Sophie} and Lehrskov, {Louise Lang} and Legaard, {Grit Elster} and Emma Dorph and Larsen, {Monica Korsager} and Natja Launbo and Fagerlind, {Sabrina Ravn} and Seide, {Sidsel Kofoed} and Stine Nymand and Maria Ball and Vinum, {Nicole Buchner} and Dahl, {Camilla N{\o}rfelt} and Marie Henneberg and Mathias Ried-Larsen and Boesen, {Mikael Ploug} and Robin Christensen and Kristian Karstoft and Rikke Krogh-Madsen and Rosenmeier, {Jaya Birgitte} and Pedersen, {Bente Klarlund} and Helga Ellingsgaard",
year = "2019",
month = "8",
day = "1",
doi = "10.1001/jamacardio.2019.2074",
language = "English",
volume = "4",
pages = "778--787",
journal = "JAMA Cardiology",
issn = "2380-6583",
publisher = "American Medical Association",
number = "8",

}

Christensen, RH, Wedell-Neergaard, AS, Lehrskov, LL, Legaard, GE, Dorph, E, Larsen, MK, Launbo, N, Fagerlind, SR, Seide, SK, Nymand, S, Ball, M, Vinum, NB, Dahl, CN, Henneberg, M, Ried-Larsen, M, Boesen, MP, Christensen, R, Karstoft, K, Krogh-Madsen, R, Rosenmeier, JB, Pedersen, BK & Ellingsgaard, H 2019, 'Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses from a Randomized Clinical Trial', JAMA Cardiology, vol. 4, no. 8, pp. 778-787. https://doi.org/10.1001/jamacardio.2019.2074

Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues : Secondary Analyses from a Randomized Clinical Trial. / Christensen, Regitse Højgaard; Wedell-Neergaard, Anne Sophie; Lehrskov, Louise Lang; Legaard, Grit Elster; Dorph, Emma; Larsen, Monica Korsager; Launbo, Natja; Fagerlind, Sabrina Ravn; Seide, Sidsel Kofoed; Nymand, Stine; Ball, Maria; Vinum, Nicole Buchner; Dahl, Camilla Nørfelt; Henneberg, Marie; Ried-Larsen, Mathias; Boesen, Mikael Ploug; Christensen, Robin; Karstoft, Kristian; Krogh-Madsen, Rikke; Rosenmeier, Jaya Birgitte; Pedersen, Bente Klarlund; Ellingsgaard, Helga.

In: JAMA Cardiology, Vol. 4, No. 8, 01.08.2019, p. 778-787.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues

T2 - Secondary Analyses from a Randomized Clinical Trial

AU - Christensen, Regitse Højgaard

AU - Wedell-Neergaard, Anne Sophie

AU - Lehrskov, Louise Lang

AU - Legaard, Grit Elster

AU - Dorph, Emma

AU - Larsen, Monica Korsager

AU - Launbo, Natja

AU - Fagerlind, Sabrina Ravn

AU - Seide, Sidsel Kofoed

AU - Nymand, Stine

AU - Ball, Maria

AU - Vinum, Nicole Buchner

AU - Dahl, Camilla Nørfelt

AU - Henneberg, Marie

AU - Ried-Larsen, Mathias

AU - Boesen, Mikael Ploug

AU - Christensen, Robin

AU - Karstoft, Kristian

AU - Krogh-Madsen, Rikke

AU - Rosenmeier, Jaya Birgitte

AU - Pedersen, Bente Klarlund

AU - Ellingsgaard, Helga

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Importance: Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots. Objective: To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass. Design, Setting, and Participants: Secondary analysis of a randomized, assessor-blinded clinical trial initiated on August 2016 and completed April 2018. This single-center, community-based study included 50 physically inactive participants with abdominal obesity. Interventions: Participants were randomized to a supervised high-intensity interval endurance training (3 times a week for 45 minutes), resistance training (3 times a week for 45 minutes), or no exercise (control group). Main Outcomes and Measures: Change in epicardial and pericardial adipose tissue mass assessed by magnetic resonance imaging, based on a prespecified secondary analysis plan including 3 of 5 parallel groups. Results: Of 50 participants (mean [SD] age, 41 [14] years, 10 men [26%]; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32 [5]), 39 [78%] completed the study. Endurance training and resistance training reduced epicardial adipose tissue mass by 32% (95% CI, 10%-53%) and 24% (95% CI, 1%-46%), respectively, compared with the no exercise control group (56% [95% CI, 24%-88%]; P =.001 and 48% [95% CI, 15%-81%]; P <.001, respectively). While there was a nonsignificant reduction in pericardial adipose tissue mass after endurance training (11% [95% CI, -5% to 27%]; P =.17), resistance training significantly reduced pericardial adipose tissue mass by 31% (95% CI, 16%-47%; P <.001) when compared with the no exercise control group. Compared with the no exercise control group, there was an increase in left ventricular mass by endurance (20 g [95% CI, 11%-30%]; P <.001) and resistance training (18 g [95% CI, 8%-28%]; P <.001). Other cardiometabolic outcomes remained unchanged after the 12-week trial period. Conclusions and Relevance: In individuals with abdominal obesity, both endurance and resistance training reduced epicardial adipose tissue mass, while only resistance training reduced pericardial adipose tissue mass. These data highlight the potential preventive importance of different exercise modalities as means to reduce cardiac fat in individuals with abdominal obesity. Trial Registration: ClinicalTrials.gov identifier: NCT02901496.

AB - Importance: Epicardial and pericardial adipose tissues are emerging as important risk factors for cardiovascular disease, and there is a growing interest in discovering strategies to reduce the accumulation of fat in these depots. Objective: To investigate whether a 12-week endurance or resistance training intervention regulates epicardial and pericardial adipose tissue mass. Design, Setting, and Participants: Secondary analysis of a randomized, assessor-blinded clinical trial initiated on August 2016 and completed April 2018. This single-center, community-based study included 50 physically inactive participants with abdominal obesity. Interventions: Participants were randomized to a supervised high-intensity interval endurance training (3 times a week for 45 minutes), resistance training (3 times a week for 45 minutes), or no exercise (control group). Main Outcomes and Measures: Change in epicardial and pericardial adipose tissue mass assessed by magnetic resonance imaging, based on a prespecified secondary analysis plan including 3 of 5 parallel groups. Results: Of 50 participants (mean [SD] age, 41 [14] years, 10 men [26%]; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32 [5]), 39 [78%] completed the study. Endurance training and resistance training reduced epicardial adipose tissue mass by 32% (95% CI, 10%-53%) and 24% (95% CI, 1%-46%), respectively, compared with the no exercise control group (56% [95% CI, 24%-88%]; P =.001 and 48% [95% CI, 15%-81%]; P <.001, respectively). While there was a nonsignificant reduction in pericardial adipose tissue mass after endurance training (11% [95% CI, -5% to 27%]; P =.17), resistance training significantly reduced pericardial adipose tissue mass by 31% (95% CI, 16%-47%; P <.001) when compared with the no exercise control group. Compared with the no exercise control group, there was an increase in left ventricular mass by endurance (20 g [95% CI, 11%-30%]; P <.001) and resistance training (18 g [95% CI, 8%-28%]; P <.001). Other cardiometabolic outcomes remained unchanged after the 12-week trial period. Conclusions and Relevance: In individuals with abdominal obesity, both endurance and resistance training reduced epicardial adipose tissue mass, while only resistance training reduced pericardial adipose tissue mass. These data highlight the potential preventive importance of different exercise modalities as means to reduce cardiac fat in individuals with abdominal obesity. Trial Registration: ClinicalTrials.gov identifier: NCT02901496.

U2 - 10.1001/jamacardio.2019.2074

DO - 10.1001/jamacardio.2019.2074

M3 - Journal article

VL - 4

SP - 778

EP - 787

JO - JAMA Cardiology

JF - JAMA Cardiology

SN - 2380-6583

IS - 8

ER -