Economic evaluation alongside a randomized controlled trial of blended cognitive-behavioral therapy for patients suffering from major depressive disorder

Astrid Langergaard, Kim Mathiasen, Jesper Søndergaard, Sabrina S. Sørensen, Sidsel L. Laursen, Alexander A.P. Xylander, Mia B. Lichtenstein, Lars H. Ehlers*

*Corresponding author for this work

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Abstract

Objective: This study aimed to investigate the cost-effectiveness of blended cognitive-behavioral therapy (CBT) compared to standard CBT for adult patients suffering from major depressive disorder (MDD). Design: A cost-utility analysis alongside the randomized controlled ENTER trial. Setting: Center for Telepsychiatry, Mental Health Services in the Region of Southern Denmark, Denmark. Participants: The study included 76 patients suffering from MDD. Interventions: The patients in the intervention group received blended CBT treatment comprising a combination of online modules and face-to-face consultations with a psychologist. The patients in the control group received standard CBT treatment, that is, solely face-to-face consultations with a psychologist. The treatment period was 12 weeks. Outcome measures: Cost-effectiveness was reported as incremental cost-effectiveness ratio. A micro-costing approach was applied to evaluate the savings derived. Changes in quality-adjusted life-years (QALYs) were estimated using the EuroQol 5-Dimensions 5-Levels questionnaire at the baseline and the six-month follow-up. Results: Data for 74 patients were included in the primary analysis. The adjusted QALY difference between blended CBT and standard CBT was −0.0291 (95% CI: −0.0535 to −0.0047), and the adjusted difference in costs was -£226.32 (95% CI: −300.86 to −151.77). Blended CBT was estimated to have a 6.6% and 3.1% probability of being cost-effective based on thresholds of £20,000 and £30,000. Conclusion: Compared to standard CBT, blended CBT represents a cost-saving but also a loss in QALYs for patients suffering from MDD. However, results should be carefully interpreted, given the small sample size. Future research involving larger replication studies focusing on other aspects of blended CBT with more patient involvement is advised. Trial registration number: ClinicalTrial.gov: S-20150150.

Original languageEnglish
Article number100513
JournalInternet Interventions
Volume28
Number of pages7
ISSN2214-7829
DOIs
Publication statusPublished - Apr 2022

Bibliographical note

Publisher Copyright:
© 2022

Keywords

  • Cognitive behavioral therapy
  • Cost-utility
  • Economic evaluation
  • Internet intervention
  • Major depressive disorder
  • mHealth

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