Early exposure to smoking and future fecundity among Danish twins.

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Several studies have examined the effect of in utero exposure to smoking and fecundity among the offspring but the findings are contradictory. We therefore studied the waiting time to first pregnancy (TTP) and exposure to smoking in utero and childhood among Danish twins born between 1931 and 1952. Information about TTP, exposure to mothers smoking in pregnancy, exposure to smoking in childhood and current smoking among the male twins and smoking in their own pregnancy among female twins was collected by interview. Fecundability odds ratio (FOR) estimating the odds of conception in a cycle among exposed compared to the unexposed were calculated separately for female and male twins. A total of 1653 female and 1598 male twins reported a TTP. Female twins, exposed in utero, had reduced fecundability after control for confounders (FOR = 0.81; 95% CI 0.67–0.99). A nonsignificant increase in fecundity among male twins exposed to smoking in utero was found (FOR = 1.12; 95% CI 0.89–1.40). Among dizygotic twins of opposite sex sharing the same in utero exposures, the future fecundity of the male twin was unaffected by in utero exposure (FOR = 0.97; 95% CI 0.60–1.55) whereas the female twin had reduced fecundity (FOR = 0.65; 95% CI 0.47–0.91). This study supports that smoking is hazardous to the female fetus not only in the short term but also affects her future ability to conceive and makes it even more important to advise pregnant women to stop smoking.

Original languageEnglish
JournalInternational Journal of Andrology
Volume29
Pages (from-to)603-613
Number of pages11
ISSN0105-6263
DOIs
Publication statusPublished - 2006

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Smoking
Odds Ratio
Dizygotic Twins
Pregnant Women
Fetus
Mothers
Interviews

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@article{ffd44680e0f611db9628000ea68e967b,
title = "Early exposure to smoking and future fecundity among Danish twins.",
abstract = "Several studies have examined the effect of in utero exposure to smoking and fecundity among the offspring but the findings are contradictory. We therefore studied the waiting time to first pregnancy (TTP) and exposure to smoking in utero and childhood among Danish twins born between 1931 and 1952. Information about TTP, exposure to mothers smoking in pregnancy, exposure to smoking in childhood and current smoking among the male twins and smoking in their own pregnancy among female twins was collected by interview. Fecundability odds ratio (FOR) estimating the odds of conception in a cycle among exposed compared to the unexposed were calculated separately for female and male twins. A total of 1653 female and 1598 male twins reported a TTP. Female twins, exposed in utero, had reduced fecundability after control for confounders (FOR = 0.81; 95{\%} CI 0.67–0.99). A nonsignificant increase in fecundity among male twins exposed to smoking in utero was found (FOR = 1.12; 95{\%} CI 0.89–1.40). Among dizygotic twins of opposite sex sharing the same in utero exposures, the future fecundity of the male twin was unaffected by in utero exposure (FOR = 0.97; 95{\%} CI 0.60–1.55) whereas the female twin had reduced fecundity (FOR = 0.65; 95{\%} CI 0.47–0.91). This study supports that smoking is hazardous to the female fetus not only in the short term but also affects her future ability to conceive and makes it even more important to advise pregnant women to stop smoking.",
author = "Jensen, {Tina Kold} and Michael Joffe and Thomas Scheike and Axel Skytthe and David Gaist and Inge Petersen and Kaare Christensen",
year = "2006",
doi = "10.1111/j.1365-2605.2006.00701.x",
language = "English",
volume = "29",
pages = "603--613",
journal = "International Journal of Andrology",
issn = "0105-6263",
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}

Early exposure to smoking and future fecundity among Danish twins. / Jensen, Tina Kold; Joffe, Michael; Scheike, Thomas; Skytthe, Axel; Gaist, David; Petersen, Inge; Christensen, Kaare.

In: International Journal of Andrology, Vol. 29, 2006, p. 603-613.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Early exposure to smoking and future fecundity among Danish twins.

AU - Jensen, Tina Kold

AU - Joffe, Michael

AU - Scheike, Thomas

AU - Skytthe, Axel

AU - Gaist, David

AU - Petersen, Inge

AU - Christensen, Kaare

PY - 2006

Y1 - 2006

N2 - Several studies have examined the effect of in utero exposure to smoking and fecundity among the offspring but the findings are contradictory. We therefore studied the waiting time to first pregnancy (TTP) and exposure to smoking in utero and childhood among Danish twins born between 1931 and 1952. Information about TTP, exposure to mothers smoking in pregnancy, exposure to smoking in childhood and current smoking among the male twins and smoking in their own pregnancy among female twins was collected by interview. Fecundability odds ratio (FOR) estimating the odds of conception in a cycle among exposed compared to the unexposed were calculated separately for female and male twins. A total of 1653 female and 1598 male twins reported a TTP. Female twins, exposed in utero, had reduced fecundability after control for confounders (FOR = 0.81; 95% CI 0.67–0.99). A nonsignificant increase in fecundity among male twins exposed to smoking in utero was found (FOR = 1.12; 95% CI 0.89–1.40). Among dizygotic twins of opposite sex sharing the same in utero exposures, the future fecundity of the male twin was unaffected by in utero exposure (FOR = 0.97; 95% CI 0.60–1.55) whereas the female twin had reduced fecundity (FOR = 0.65; 95% CI 0.47–0.91). This study supports that smoking is hazardous to the female fetus not only in the short term but also affects her future ability to conceive and makes it even more important to advise pregnant women to stop smoking.

AB - Several studies have examined the effect of in utero exposure to smoking and fecundity among the offspring but the findings are contradictory. We therefore studied the waiting time to first pregnancy (TTP) and exposure to smoking in utero and childhood among Danish twins born between 1931 and 1952. Information about TTP, exposure to mothers smoking in pregnancy, exposure to smoking in childhood and current smoking among the male twins and smoking in their own pregnancy among female twins was collected by interview. Fecundability odds ratio (FOR) estimating the odds of conception in a cycle among exposed compared to the unexposed were calculated separately for female and male twins. A total of 1653 female and 1598 male twins reported a TTP. Female twins, exposed in utero, had reduced fecundability after control for confounders (FOR = 0.81; 95% CI 0.67–0.99). A nonsignificant increase in fecundity among male twins exposed to smoking in utero was found (FOR = 1.12; 95% CI 0.89–1.40). Among dizygotic twins of opposite sex sharing the same in utero exposures, the future fecundity of the male twin was unaffected by in utero exposure (FOR = 0.97; 95% CI 0.60–1.55) whereas the female twin had reduced fecundity (FOR = 0.65; 95% CI 0.47–0.91). This study supports that smoking is hazardous to the female fetus not only in the short term but also affects her future ability to conceive and makes it even more important to advise pregnant women to stop smoking.

U2 - 10.1111/j.1365-2605.2006.00701.x

DO - 10.1111/j.1365-2605.2006.00701.x

M3 - Journal article

VL - 29

SP - 603

EP - 613

JO - International Journal of Andrology

JF - International Journal of Andrology

SN - 0105-6263

ER -