Dynamic multi-pinhole collimated brain SPECT of Parkinson’s disease by [123I]FP-CIT: a feasibility study of fSPECT

Filip L.H. Fredensborg*, Kasper Thilsing-Hansen, Jane A. Simonsen, Peter Grupe, Ziba A. Farahani, Christian W. Andersen, Albert Gjedde, Svend Hvidsten

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We investigated the feasibility of using a dopamine transporter (DaT) tracer ligand ([123I]FP-CIT) along with novel multi-pinhole brain collimators for dynamic brain single photon emission computed tomography (SPECT) in suspected Parkinson's disease patients. Thirteen patients underwent dynamic tracer acquisitions before standard imaging. Uptake values were corrected for partial volume effects. Specific binding ratio (SBRcalc) was calculated, reflecting binding potential relative to non-displaceable binding (BPND) in the cortex. Additional pharmacokinetic parameters (BPND, R1, k2) were estimated using the simplified reference tissue model, revealing differences between Kahraman low-score (LS) and high-score (HS) groups. Results showed increasing striatal tracer uptake until 100 min post-injection, with consistent values afterward. Uptake and SBRcalc ratios matched visual assessment. LS patients had lower putamen than caudate nucleus tracer uptake, decreased BPND values, while R1 and k2 values were comparable to HS patients. In conclusion, dynamic multi-pinhole SPECT using DaT tracer with the extraction of pharmacokinetic parameters is feasible and could help enable early differentiation of reduced and normal DaT values.

Original languageEnglish
Article number6624
JournalScientific Reports
Volume14
Number of pages11
ISSN2045-2322
DOIs
Publication statusPublished - 19. Mar 2024

Keywords

  • Brain/diagnostic imaging
  • Dopamine Plasma Membrane Transport Proteins/metabolism
  • Feasibility Studies
  • Humans
  • Parkinson Disease/diagnostic imaging
  • Putamen/metabolism
  • Tomography, Emission-Computed, Single-Photon/methods
  • Tropanes/metabolism

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