Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides

Kasper Munch Beck; Pawan K. Sharma; Mick Hornum; Nikolaj Risgaard; Poul Nielsen

doi:10.1039/D1CC03539H

Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides

Kasper Munch Beck, Pawan K. Sharma, Mick Hornum, Nikolaj Risgaard, Poul Nielsen^*

^*Corresponding author for this work

Department of Physics, Chemistry and Pharmacy

Kurukshetra University

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.

Original language	English
Journal	Chemical Communications
Volume	57
Issue number	72
Pages (from-to)	9128-9131
ISSN	1359-7345
DOIs	https://doi.org/10.1039/D1CC03539H
Publication status	Published - Sept 2021

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10.1039/D1CC03539H

Open Access VersionAccepted manuscript, 875 KB

1 Ph.D. thesis

Nucleic Acids with Condensed Information
Beck, K. M., 10. Feb 2022, Syddansk Universitet. Det Naturvidenskabelige Fakultet. 375 p.
Research output: Thesis › Ph.D. thesis

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title = "Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides",

abstract = "Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.",

author = "Beck, {Kasper Munch} and Sharma, {Pawan K.} and Mick Hornum and Nikolaj Risgaard and Poul Nielsen",

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language = "English",

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T1 - Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides

AU - Beck, Kasper Munch

AU - Sharma, Pawan K.

AU - Hornum, Mick

AU - Risgaard, Nikolaj

AU - Nielsen, Poul

PY - 2021/9

Y1 - 2021/9

N2 - Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.

AB - Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.

U2 - 10.1039/D1CC03539H

DO - 10.1039/D1CC03539H

M3 - Journal article

SN - 1359-7345

VL - 57

SP - 9128

EP - 9131

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides

Abstract

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Nucleic Acids with Condensed Information

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