Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides

Kasper Munch Beck, Pawan K. Sharma, Mick Hornum, Nikolaj Risgaard, Poul Nielsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Nucleotide monomers that hold two nucleobases each, i.e. double-headed nucleotides, have been shown to form two sets of functional Watson–Crick base pairs when incorporated into dsDNA, and they hereby behave as dinucleotides. To form the basis for fully modified double-headed nucleic acids (DhNA), we have prepared three new DhNA monomers and can now demonstrate that the molecular information of 10 Watson–Crick base pairs can be condensed to highly stable 5-mer DhNA duplexes.
Original languageEnglish
JournalChem. Commun.
Volume57
Issue number72
Pages (from-to)9128-9131
ISSN1359-7345
DOIs
Publication statusPublished - Sep 2021

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