Dose modifications of ribociclib and endocrine therapy for treatment of ER+ HER2− metastatic breast cancer

Kristoffer B. Kristensen*, Ida Marie Nedergaard Thomsen, Tobias Berg, Annette R. Kodahl, Anders Bonde Jensen

*Corresponding author for this work

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Abstract

Purpose: Treatment for estrogen receptor positive (ER+), human epidermal receptor 2 negative (HER2−) metastatic breast cancer (MBC) has improved with the approval of CDK 4/6 inhibitors. Clinical trials with the CDK4/6 inhibitor ribociclib, suggest that 35% to 57.5% of the patients require a dose reduction during ribociclib treatment. Data on the possible consequences of dose reduction concerning efficacy is needed. Methods: A retrospective cohort study on patients with ER+ HER2− MBC from three Danish oncology departments. Data on tolerability and progression-free survival were collected from electronic health records. Results: One hundred and twenty-eight patients with ER+ HER2− MBC who initiated ribociclib treatment between 1st of January 2018 to 31st of March 2020 were included in our analysis. Of these patients, 48.4% required one or more dose reductions. Overall median PFS was 19.2 months (CI-95% 14.3-NR). Patients with one or more dose reductions did not have decreased median PFS (19.2 months, CI-95% 14.3-NR compared to 12.2 months, CI-95% 7.3-NR, p = 0.078). Frequency of adverse events were as previously reported, with grade III and IV neutropenia occurring in 45.3% and 7% of patients, respectively. Patients treated with fulvestrant versus an aromatase inhibitor and patients with lymph node involvement at baseline had lower odds of requiring a dose reduction (ORa = 0.30, CI-95% 0.12–0.73 & ORa = 0.41, CI-95% 0.18–0.89, respectively). Conclusion: Our results indicate that dose reduction of ribociclib is safe and do not compromise the efficacy of the treatment. Furthermore, the study supports translation of results from the MONALEESA trials to patients treated in real-world clinical settings.

Original languageEnglish
JournalBreast Cancer Research and Treatment
Volume188
Issue number3
Pages (from-to)799-809
ISSN0167-6806
DOIs
Publication statusPublished - Aug 2021

Keywords

  • CDK 4/6 inhibitor
  • Dose modifications
  • Dose reduction
  • Metastatic breast cancer
  • Progression-free survival
  • Ribociclib
  • Aminopyridines
  • Receptors, Estrogen
  • Humans
  • Receptor, ErbB-2/genetics
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects
  • Purines
  • Female
  • Retrospective Studies
  • Breast Neoplasms/drug therapy

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