The purpose of this chapter is to investigate the relationship among supply chain innovation and performance in terms of market and operational performance. The chapter is built on empirically data subject to 187 useable responses from a questionnaire-survey among Danish manufacturers. A conceptual model was developed and subsequently two major hypotheses were formulated. Linear regression was performed using SPSS software 22.0 to tests the developed hypotheses. Supply chain innovation is unfolded through the components of business processes, networks structure and technology. Data reveals that supply chain innovation does pay off in terms of improved market and operational performance. The chapter also reveals that the strongest relationship is obtained with supply chain innovation and operational performance. Market performance may be influenced by a number of different factors beyond supply chain innovation. The chapter provides interesting findings of the network component with empirical evidence that it has a positive influence on both market and operation performance. The chapter concludes by suggesting new areas of research including also the relationship to financial performance.