Does parental farm upbringing influence the risk of asthma in offspring? A three-generation study

Signe Timm, Cecilie Svanes*, Morten Frydenberg, Torben Sigsgaard, Mathias Holm, Christer Janson, Lennart Bråbäck, Brittany Campbell, Marie Kjaer Madsen, Nils Oskar Jõgi, Rain Jõgi, Linus Schiöler, Randi Jacobsen Bertelsen, Ane Johannessen, Jose Luis Sanchez-Ramos, Jesus Martinez-Moretalla, Julia Dratva, Shyamali Dharmage, Vivi Schlünssen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. Methods: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945-1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale. Results: A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74-1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67-1.65) or paternal line (HR 1.02, 95% CI 0.62-1.68). Conclusions: This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma.

Original languageEnglish
JournalInternational Journal of Epidemiology
Volume49
Issue number6
Pages (from-to)1874-1882
ISSN0300-5771
DOIs
Publication statusPublished - 1. Dec 2020
Externally publishedYes

Keywords

  • Asthma
  • ECRHS
  • farm upbringing
  • generation study
  • generational effects
  • RHINESSA

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